Abstract
Aberrant cellular proliferation and compromised apoptotic pathways are hallmarks of cancer aggressiveness, and in this framework, the role of protein degradation machineries have been extensively dissected. Among proteases, the proteasome is unequivocally central in the intracellular regulation of both these processes, thus several proteasome-directed therapies have been investigated, aiming at controlling its activity and possibly restoring normal cell functions. Numerous studies reported proteasome inhibitors (both synthetic and natural occurring) to potently and selectively induce apoptosis in many types of cancer cells. In this review, we discuss recent advances in proteasomal modulation by some natural occurring polyphenols, globally providing evidence of the proteasome role as therapeutic target in cancer treatment.
Keywords: Apoptosis, cancer, polyphenols, proteasome
Current Cancer Drug Targets
Title: Targeting Proteasomes with Naturally Occurring Compounds in Cancer Treatment
Volume: 11 Issue: 3
Author(s): V. Cecarini, M. Cuccioloni, M. Mozzicafreddo, L. Bonfili, M. Angeletti and A. M. Eleuteri
Affiliation:
Keywords: Apoptosis, cancer, polyphenols, proteasome
Abstract: Aberrant cellular proliferation and compromised apoptotic pathways are hallmarks of cancer aggressiveness, and in this framework, the role of protein degradation machineries have been extensively dissected. Among proteases, the proteasome is unequivocally central in the intracellular regulation of both these processes, thus several proteasome-directed therapies have been investigated, aiming at controlling its activity and possibly restoring normal cell functions. Numerous studies reported proteasome inhibitors (both synthetic and natural occurring) to potently and selectively induce apoptosis in many types of cancer cells. In this review, we discuss recent advances in proteasomal modulation by some natural occurring polyphenols, globally providing evidence of the proteasome role as therapeutic target in cancer treatment.
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Cecarini V., Cuccioloni M., Mozzicafreddo M., Bonfili L., Angeletti M. and M. Eleuteri A., Targeting Proteasomes with Naturally Occurring Compounds in Cancer Treatment, Current Cancer Drug Targets 2011; 11 (3) . https://dx.doi.org/10.2174/156800911794519815
DOI https://dx.doi.org/10.2174/156800911794519815 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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