Abstract
While in the latest years carbon nanotubes have found wide exploitation in nanomedicine, to date biomedical applications of boron nitride nanotubes (BNNTs) are almost totally unexplored. BNNTs are structural analogues of carbon nanotubes: alternating B and N atoms entirely substitute for C atoms in a graphitic-like sheet, with almost no change in atomic spacing. Despite this structural similarity, BNNTs present superior chemical and physical properties that render them more amenable for a plenty of applications in the biomedical field. In this review, we summarize the major findings of the studies about the interactions between BNNTs and living matter, with special attention on the potential applications to the neuronal system, which range from the treatment of neuronal diseases, to the stimulation of neurons, up to the exploitation of BNNTs as structural reinforcement agents for tissue engineering.
Keywords: Boron nitride nanotubes, nanomedicine, neuronal cells, brain cancer therapy, nanotransducers, Therapeutic Agents, Brain Diseases, carbon nanotubes, Nanotechnology, piezoelectric polymers, boron neutron capture therapy, Cross-section morphology, chemical vapor deposition (CVD), laser heating, laser pyrolyse, plasma jet method, graphite electrodes, BN-packed tungsten rod, cooled copper electrode, plasma-arc method, Excimer laser ablation, BN multi-walled nanotubes, transmission electron microscopy (TEM), R-mannose moieties, laser scanning confocal micros-copy (LSCM), Fluorescence micros-copy, glycodendrimers, human embryonic kidney cells, Chinese hamster ovary, human osteoblasts, mouse macrophages, human neuroblastoma cells, mouse myoblasts C2C12, apoptosis, cytotoxic effect, myogenic differentiation, MyoD, Connexin 43, mitotic cells, BNNTs AS THERAPEUTIC AGENTS FOR BRAIN CAN-CER, radiotherapy
Current Nanoscience
Title: Boron Nitride Nanotubes: Production, Properties, Biological Interactions and Potential Applications as Therapeutic Agents in Brain Diseases
Volume: 7 Issue: 1
Author(s): Gianni Ciofani, Serena Danti, Leonardo Ricotti, Delfo D'Alessandro, Stefania Moscato, Stefano Berrettini, Virgilio Mattoli and Arianna Menciassi
Affiliation:
Keywords: Boron nitride nanotubes, nanomedicine, neuronal cells, brain cancer therapy, nanotransducers, Therapeutic Agents, Brain Diseases, carbon nanotubes, Nanotechnology, piezoelectric polymers, boron neutron capture therapy, Cross-section morphology, chemical vapor deposition (CVD), laser heating, laser pyrolyse, plasma jet method, graphite electrodes, BN-packed tungsten rod, cooled copper electrode, plasma-arc method, Excimer laser ablation, BN multi-walled nanotubes, transmission electron microscopy (TEM), R-mannose moieties, laser scanning confocal micros-copy (LSCM), Fluorescence micros-copy, glycodendrimers, human embryonic kidney cells, Chinese hamster ovary, human osteoblasts, mouse macrophages, human neuroblastoma cells, mouse myoblasts C2C12, apoptosis, cytotoxic effect, myogenic differentiation, MyoD, Connexin 43, mitotic cells, BNNTs AS THERAPEUTIC AGENTS FOR BRAIN CAN-CER, radiotherapy
Abstract: While in the latest years carbon nanotubes have found wide exploitation in nanomedicine, to date biomedical applications of boron nitride nanotubes (BNNTs) are almost totally unexplored. BNNTs are structural analogues of carbon nanotubes: alternating B and N atoms entirely substitute for C atoms in a graphitic-like sheet, with almost no change in atomic spacing. Despite this structural similarity, BNNTs present superior chemical and physical properties that render them more amenable for a plenty of applications in the biomedical field. In this review, we summarize the major findings of the studies about the interactions between BNNTs and living matter, with special attention on the potential applications to the neuronal system, which range from the treatment of neuronal diseases, to the stimulation of neurons, up to the exploitation of BNNTs as structural reinforcement agents for tissue engineering.
Export Options
About this article
Cite this article as:
Ciofani Gianni, Danti Serena, Ricotti Leonardo, D'Alessandro Delfo, Moscato Stefania, Berrettini Stefano, Mattoli Virgilio and Menciassi Arianna, Boron Nitride Nanotubes: Production, Properties, Biological Interactions and Potential Applications as Therapeutic Agents in Brain Diseases, Current Nanoscience 2011; 7 (1) . https://dx.doi.org/10.2174/157341311794480345
DOI https://dx.doi.org/10.2174/157341311794480345 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Involvement of Uric Acid in the Pathogenesis of Preeclampsia
Current Hypertension Reviews Specific Hemosiderin Deposition in Spleen Induced by a Low Dose of Cisplatin: Altered Iron Metabolism and Its Implication as an Acute Hemosiderin Formation Model
Current Drug Metabolism The Role of Dietary Polyphenols in the Management of Inflammatory Bowel Disease
Current Pharmaceutical Biotechnology Inhibitors of HIV-1 Protease: Current State of the Art 10 Years After their Introduction. From Antiretroviral Drugs to Antifungal, Antibacterial and Antitumor Agents Based on Aspartic Protease Inhibitors
Current Medicinal Chemistry Stem Cells and Bioactive Scaffolds as a Treatment for Traumatic Brain Injury
Current Stem Cell Research & Therapy Soluble Diphtheria Toxin Variant, CRM 197 was Obtained in <i>Escherichia coli</i> at High Productivity Using SUMO Fusion and an Adjusted Expression Strategy
Protein & Peptide Letters Imaging of Cyclooxygenase-2 (COX-2) Expression: Potential Use in Diagnosis and Drug Evaluation
Current Pharmaceutical Design A Review of Diagnostic Reference Levels in Computed Tomography
Current Medical Imaging Quality of Life of Children with Type 1 Diabetes: A Systematic Review
Current Diabetes Reviews Effects of Physical Exercise on Depressive Symptoms and Biomarkers in Depression
CNS & Neurological Disorders - Drug Targets Recent Advances in Targeted Anti-Vasculature Therapy: The Neuroblastoma Model
Current Drug Targets Single Nucleotide Polymorphisms in Neonatal Necrotizing Enterocolitis
Current Pediatric Reviews The Pathogenic Subpopulation of Th17 Cells in Obesity
Current Pharmaceutical Design The Innate Immune System and Fever under Redox Control: A Narrative Review
Current Medicinal Chemistry Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System
Current Stem Cell Research & Therapy Gene Therapy in Liver Diseases: State-of-the-Art and Future Perspectives
Current Gene Therapy Role of mTOR in Hematological Malignancies
Current Cancer Therapy Reviews A Bibliometric Analysis of Global Research on Lophomonas Spp. in Scopus (1933-2019)
Infectious Disorders - Drug Targets Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide
Current Drug Metabolism The Nuclear Molecular Imaging of Protein Brain Receptors in Chronic Pain
Current Protein & Peptide Science