Abstract
SUMOylation, a posttranslational modification process in which SUMO, the small ubiquitin-related modifier or small ubiquitin-like modifier, is added to the target proteins, plays an important role in regulating a variety of cellular processes including protein-protein interactions, subcellular localization, protein-DNA interactions and enzyme activity. This process adds another layer of control in eukaryote gene expression, and it regulates both transcriptional activation and repression. In the present review, we summarized the currently emerging information regarding the function of SUMOylation in ocular development and pathology.
Keywords: SUMOylation, gene expression, retina, lens, cornea, Pax-6, LEDGF, Nr2e3, Nrl, development, differentiation, signal transduction, ubiquitination, transcription, environmental stimuli, homeostasis, conjugated, proteeasome, sentrin-specific proteases, erythroleukemia, Histone deacetylase, rhodopsin, homeodomain genes, enhanceosome, mutations, neuroretina, rostral telencephalon, immunohistochemistry, neuroectoderm, pseudo-optic, autoimmunity
Current Molecular Medicine
Title: SUMOylation in Ocular Development and Pathology
Volume: 10 Issue: 9
Author(s): L. Gong and D. W.-C. Li
Affiliation:
Keywords: SUMOylation, gene expression, retina, lens, cornea, Pax-6, LEDGF, Nr2e3, Nrl, development, differentiation, signal transduction, ubiquitination, transcription, environmental stimuli, homeostasis, conjugated, proteeasome, sentrin-specific proteases, erythroleukemia, Histone deacetylase, rhodopsin, homeodomain genes, enhanceosome, mutations, neuroretina, rostral telencephalon, immunohistochemistry, neuroectoderm, pseudo-optic, autoimmunity
Abstract: SUMOylation, a posttranslational modification process in which SUMO, the small ubiquitin-related modifier or small ubiquitin-like modifier, is added to the target proteins, plays an important role in regulating a variety of cellular processes including protein-protein interactions, subcellular localization, protein-DNA interactions and enzyme activity. This process adds another layer of control in eukaryote gene expression, and it regulates both transcriptional activation and repression. In the present review, we summarized the currently emerging information regarding the function of SUMOylation in ocular development and pathology.
Export Options
About this article
Cite this article as:
Gong L. and W.-C. Li D., SUMOylation in Ocular Development and Pathology, Current Molecular Medicine 2010; 10 (9) . https://dx.doi.org/10.2174/156652410793937769
DOI https://dx.doi.org/10.2174/156652410793937769 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Possible Neuroprotective Strategies for Huntingtons Disease
Current Neuropharmacology Preclinical Analyses of the Therapeutic Potential of Allopregnanolone to Promote Neurogenesis In Vitro and In Vivo in Transgenic Mouse Model of Alzheimers Disease
Current Alzheimer Research Capillary Electrophoresis with Mass Spectrometry: Applications to Metabolomic Analysis
Current Metabolomics Cocaine and HIV-1 Interplay in CNS: Cellular and Molecular Mechanisms
Current HIV Research CB1 Cannabinoid Receptors and their Associated Proteins
Current Medicinal Chemistry Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System?
Current Medicinal Chemistry Elucidating the Risk Factors for Progression from Amyloid-Negative Amnestic Mild Cognitive Impairment to Dementia
Current Alzheimer Research An EJC Factor RBM8a Regulates Anxiety Behaviors
Current Molecular Medicine The Response of the Aged Brain to Stroke: Too Much, Too Soon?
Current Neurovascular Research Neuroprotective Properties of Erythropoietin in Cerebral Ischemia
Central Nervous System Agents in Medicinal Chemistry Update on Medical and Surgical Management of Intracerebral Hemorrhage
Reviews on Recent Clinical Trials Extracellular ATP and Neurodegeneration
Current Drug Targets - CNS & Neurological Disorders Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review
Current Medicinal Chemistry Glutamate and Schizophrenia
Current Neuropharmacology D-Serine Regulation: A Possible Therapeutic Approach for Central Nervous Diseases and Chronic Pain
Mini-Reviews in Medicinal Chemistry AMPA Receptors in the Therapeutic Management of Depression
CNS & Neurological Disorders - Drug Targets Ligands for Fluorescence Correlation Spectroscopy on G Protein-Coupled Receptors
Current Medicinal Chemistry The Regulation of Neuroimmune-Endocrine Interactions: Mechanisms,Molecular Pathways Unraveled and the Pivotal Role of Cytokines – A Unsung Putative Bidirectional Interdependence between the Immune and Neuroendocrine Interfaces
Current Immunology Reviews (Discontinued) The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue
CNS & Neurological Disorders - Drug Targets Neuroprotection Abilities of Cytosolic Phospholipase A2 Inhibitors in Kainic acid-induced Neurodegeneration
Current Drug Targets - Cardiovascular & Hematological Disorders