Abstract
Glucocorticoids play an essential role in embryonic development and tissue homeostasis and possess important antiinflammatory and immunosuppressive properties. Due to their very wide spectrum of activity, glucocorticoids are one of the most commonly used drugs-used in the treatment of asthma, arthritis, autoimmune diseases and shock/SIRS. Glucocorticoids are a main component of treatment regimens in hematological malignancies due to their pro-apoptotic properties and are also used as co-treatment several other cancers and chemotherapy regimens including those in breast cancer treatment. In breast cancer, however, glucocorticoids may have diverse effects and could inhibit chemosensitivity. Additionally, glucocorticoids through their receptor may interact with ER in a feedback loop regulating each others activities. The normal variation of glucocorticoid levels with time of the day, menstrual cycle or year could have a interesting chronobiological interaction with the well recorded variation in breast cancer proliferation and metastatic potential. Glucocorticoids could play a very complex role in breast cancer epidemiology, biology and treatment; this review aims to present a comprehensive discussion as well as speculate future directions for research.
Keywords: Glucocorticoids, steroids, breast cancer, review, circadian, paracrine, glucocorticoid receptor, treatment, homeostasis, asthma, arthritis, autoimmune diseases, chemotherapy, leukemia, lymphoma, CNS, Oestrogen, progesterone, nuclear factor-B, Dexomethasone, sulfotransferase, rheumatoid arthritis, metabolic syndrome, NSAID, MCF10A-Myc mammary carcinoma cells, RU486, SGK-1, Serum and glucocorticoid induced Kinase 1, MAP kinase phosphatase-1, Trastuzumab-induced cell growth, CIRCADIAN RHYTHMS, Estrogen receptors, Human Epidermal Growth Factor Receptor-2, Endocrine Therapy
Current Pharmaceutical Design
Title: Role of Glucocorticoids in Breast Cancer
Volume: 16 Issue: 32
Author(s): Jayant S. Vaidya, Gustavo Baldassarre, Mangesh A. Thorat and Samuele Massarut
Affiliation:
Keywords: Glucocorticoids, steroids, breast cancer, review, circadian, paracrine, glucocorticoid receptor, treatment, homeostasis, asthma, arthritis, autoimmune diseases, chemotherapy, leukemia, lymphoma, CNS, Oestrogen, progesterone, nuclear factor-B, Dexomethasone, sulfotransferase, rheumatoid arthritis, metabolic syndrome, NSAID, MCF10A-Myc mammary carcinoma cells, RU486, SGK-1, Serum and glucocorticoid induced Kinase 1, MAP kinase phosphatase-1, Trastuzumab-induced cell growth, CIRCADIAN RHYTHMS, Estrogen receptors, Human Epidermal Growth Factor Receptor-2, Endocrine Therapy
Abstract: Glucocorticoids play an essential role in embryonic development and tissue homeostasis and possess important antiinflammatory and immunosuppressive properties. Due to their very wide spectrum of activity, glucocorticoids are one of the most commonly used drugs-used in the treatment of asthma, arthritis, autoimmune diseases and shock/SIRS. Glucocorticoids are a main component of treatment regimens in hematological malignancies due to their pro-apoptotic properties and are also used as co-treatment several other cancers and chemotherapy regimens including those in breast cancer treatment. In breast cancer, however, glucocorticoids may have diverse effects and could inhibit chemosensitivity. Additionally, glucocorticoids through their receptor may interact with ER in a feedback loop regulating each others activities. The normal variation of glucocorticoid levels with time of the day, menstrual cycle or year could have a interesting chronobiological interaction with the well recorded variation in breast cancer proliferation and metastatic potential. Glucocorticoids could play a very complex role in breast cancer epidemiology, biology and treatment; this review aims to present a comprehensive discussion as well as speculate future directions for research.
Export Options
About this article
Cite this article as:
S. Vaidya Jayant, Baldassarre Gustavo, A. Thorat Mangesh and Massarut Samuele, Role of Glucocorticoids in Breast Cancer, Current Pharmaceutical Design 2010; 16 (32) . https://dx.doi.org/10.2174/138161210793797906
DOI https://dx.doi.org/10.2174/138161210793797906 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel Therapies Against Aggressive and Recurrent Epithelial Cancers by Molecular Targeting Tumor- and Metastasis-Initiating Cells and Their Progenies
Anti-Cancer Agents in Medicinal Chemistry DNA Damage Response Pathways and Cell Cycle Checkpoints in Colorectal Cancer: Current Concepts and Future Perspectives for Targeted Treatment
Current Cancer Drug Targets Expression Level and Hormonal Regulation of ABC Transporters in Breast Cancer
Current Cancer Therapy Reviews Inhibitors of 17β-Hydroxysteroid Dehydrogenases
Current Medicinal Chemistry RAGE: A Single Receptor for Several Ligands and Different Cellular Responses: The Case of Certain S100 Proteins
Current Molecular Medicine Artificial O2 Carriers: Status in 2005
Current Pharmaceutical Design Sentinel Node Biopsy in Early Breast Cancer
Medicinal Chemistry The Role of Mesothelin in Tumor Progression and Targeted Therapy
Anti-Cancer Agents in Medicinal Chemistry Recent Development in the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors for Non-small Cell Lung Cancer
Current Medicinal Chemistry HSV-1 Viral Oncolysis and Molecular Imaging with PET
Current Cancer Drug Targets Autophagy and Crohns Disease: At the Crossroads of Infection, Inflammation, Immunity, and Cancer
Current Molecular Medicine Transdermal Drug Delivery: A Step towards Treatment of Cancer
Recent Patents on Anti-Cancer Drug Discovery LHRH Targeted Chonderosomes of Mitomycin C in Breast Cancer: An In Vitro/ In Vivo Study
Anti-Cancer Agents in Medicinal Chemistry A Rare Case Report of Inguinal Herniation with Urinary Bladder as its Content
New Emirates Medical Journal Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update
Current Medicinal Chemistry Novel Series of Coumarinyl Substituted-thiazolidin-2,4-dione Analogs as Anticancer Agents: Design, Synthesis, Spectral Studies and Cytotoxicity Evaluation
Anti-Cancer Agents in Medicinal Chemistry Anthrax Fusion Protein Therapy of Cancer
Current Protein & Peptide Science Triple Negative Breast Cancer - BCL2 in Prognosis and Prediction. Review
Current Drug Targets Anti-carcinogenic Effect of Cathepsin K Inhibitor, Odanacatib with a Low Dose of Cisplatin Against Human Breast Carcinoma MCF-7 and MDA-MB231 Cells
Current Cancer Therapy Reviews Editorial [Hot topic: Developing New Anti-Cancer Drugs (Guest Editor: Ricardo De Souza Pereira)]
Recent Patents on Anti-Cancer Drug Discovery