Alpha-1 Antitrypsin: It’s Role in Health and Disease

Title:Alpha-1 Antitrypsin: It’s Role in Health and Disease

Volume: 9 Issue: 4

Author(s): Mohammad Hashemi, Pawan Sharma, Mehdi Eshraghi, Mohammad Naderi, Abdolkarim Moazeni-Roodi, Hamid Mehrabifar and Mohsen Taheri

Affiliation:

Keywords: Alpha 1-antitrypsin, serine protease inhibitors, SERPIN.

Abstract: Alpha-1 Antitrypsin (AAT) is a 52 kDa glycoprotein that is principally synthesized by the liver. It is the archetype of the serine protease inhibitor (Serpin) superfamily of proteins, which has a major role in inactivating neutrophil elastase and other proteases to retain protease–antiprotease equilibrium. AAT deficiency is a rare monogenic disorder characterized by low levels of AAT in serum and the lungs and it is well known to be associated with emphysema and liver disease. Inadequate knowledge of AAT deficiency might be due to under-recognition of this protein. To date, the exact role of AAT deficiency in various diseases has not been extensively elucidated. In this review, the current knowledge regarding the role AAT in various disorders will be discussed.

Cite this article as:

Hashemi Mohammad, Sharma Pawan, Eshraghi Mehdi, Naderi Mohammad, Moazeni-Roodi Abdolkarim, Mehrabifar Hamid and Taheri Mohsen, Alpha-1 Antitrypsin: It’s Role in Health and Disease, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2010; 9 (4) . https://dx.doi.org/10.2174/1871523011009040279