Abstract
Enzyme inhibitors are important tools of nature for regulating the activity of enzymes in case of emergency. Proteinaceous inhibitors are the best studied in this group. Comparatively less is known about the inhibitors of α-amylase, which might be an attractive candidate having potentials in various fields, from the treatment of diabetes to crop protection. The area has benefited from the recent determination of structures of α-amylases, inhibitors and complexes. Besides, discussing various types of α-amylase inhibitors and their structural basis of inhibition, the biotechnological approaches for exploitation of its inhibitory function have been outlined in this minireview.
Keywords: Amylase, inhibitor, acarbose, starch, diabetes, Proteinaceous inhibitors, α-amylase, phytopathogenic microorganisms, transgenic plants, Eleusine coracana, porcine pancreas (PPA), Streptomyces, Sorghum, Trichoderma resei, 3-D structure, hyperglycemia, acarviosine-glucose, α-amylase inhibitor, Apostolidis, γ-purothionin, thaumatin, Tribolium castaneum, bruchids, pig pancreatic α-amylase, Ragi bifunctional inhibitor, sorghum inhibitor, Ragi α-amylase/trypsin inhibitor, Barley α-amylase/subtilisin inhibitor
Current Enzyme Inhibition
Title: α-Amylase Inhibition: Some Practical Considerations
Volume: 6 Issue: 3
Author(s): Om Prakash and Nivedita Jaiswal
Affiliation:
Keywords: Amylase, inhibitor, acarbose, starch, diabetes, Proteinaceous inhibitors, α-amylase, phytopathogenic microorganisms, transgenic plants, Eleusine coracana, porcine pancreas (PPA), Streptomyces, Sorghum, Trichoderma resei, 3-D structure, hyperglycemia, acarviosine-glucose, α-amylase inhibitor, Apostolidis, γ-purothionin, thaumatin, Tribolium castaneum, bruchids, pig pancreatic α-amylase, Ragi bifunctional inhibitor, sorghum inhibitor, Ragi α-amylase/trypsin inhibitor, Barley α-amylase/subtilisin inhibitor
Abstract: Enzyme inhibitors are important tools of nature for regulating the activity of enzymes in case of emergency. Proteinaceous inhibitors are the best studied in this group. Comparatively less is known about the inhibitors of α-amylase, which might be an attractive candidate having potentials in various fields, from the treatment of diabetes to crop protection. The area has benefited from the recent determination of structures of α-amylases, inhibitors and complexes. Besides, discussing various types of α-amylase inhibitors and their structural basis of inhibition, the biotechnological approaches for exploitation of its inhibitory function have been outlined in this minireview.
Export Options
About this article
Cite this article as:
Prakash Om and Jaiswal Nivedita, α-Amylase Inhibition: Some Practical Considerations, Current Enzyme Inhibition 2010; 6 (3) . https://dx.doi.org/10.2174/157340810793384089
DOI https://dx.doi.org/10.2174/157340810793384089 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Diabetes, Diabetic Complications, and Phosphate Toxicity: A Scoping Review
Current Diabetes Reviews Death by Insulin: Management of Self-Harm and Suicide in Diabetes Management
Current Diabetes Reviews Withdrawal Notice: Burden of Thyroid Dysfunction on Type 2 Diabetes Mellitus Patients with Emphasis on its Prevalence and Pattern of Presentation: A Case Controlled Study
Current Diabetes Reviews Interindividual Variability in the Efficacy of Oral Antiplatelet Drugs: Definitions, Mechanisms and Clinical Importance
Current Pharmaceutical Design Dietary Fatty Acids in Metabolic Syndrome, Diabetes and Cardiovascular Diseases
Current Diabetes Reviews Polycystic Ovary Syndrome as a Proinflammatory State: The Role of Adipokines
Current Pharmaceutical Design Secondary Metabolites in the Treatment of Diabetes Mellitus: A Paradigm Shift
Current Drug Metabolism Prevalence of Foot Ulcers, Foot at Risk and Associated Risk Factors Among Jordanian Diabetics
Current Diabetes Reviews Nonalcoholic Fatty Liver Disease and Cardiovascular Disease
Current Pharmaceutical Design A Multicenter Prospective Hospital-based Cohort Study on the Efficacy and Safety of Pitavastatin
Current Diabetes Reviews Dendritic Cells: A New Player in Osteoimmunology
Current Molecular Medicine Sex Differences in Clinical Outcomes of Patients with Stable Coronary Artery Disease after Percutaneous Coronary Intervention
Current Pharmaceutical Design GuidAge Study: A 5-Year Double Blind, Randomised Trial of EGb 761 for the Prevention of Alzheimers Disease in Elderly Subjects with Memory Complaints. I. Rationale, Design and Baseline Data
Current Alzheimer Research Clinical Presentation, Diagnostic Work-Up, and Treatment of Coronary In-Stent Restenosis
Vascular Disease Prevention (Discontinued) Bioactive Compounds Containing Benzoxadiazole, Benzothiadiazole, Benzotriazole
Current Bioactive Compounds Spinal Cord Injury Changes Cytokine Transport
CNS & Neurological Disorders - Drug Targets Anti-hyperglycemic Potential of Natural Products
Mini-Reviews in Medicinal Chemistry Non-Alcoholic Fatty Liver Disease in Children
Current Nutrition & Food Science Epicardial and Intramyocardial Adipose Tissue: The Enemy within
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Nutritional Control, Gene Regulation, and Transformation of Vascular Smooth Muscle Cells in Atherosclerosis
Cardiovascular & Hematological Disorders-Drug Targets