Abstract
Although not frequently mutated in prostate cancer Ras isoforms play a pivotal role in multiple pathways that have been implicated in prostate cancer progression to androgen independence. These have included growth factor and cytokine induced activation of the androgen receptor and its coregulators by post translational modification. Current evidence suggests that Ras is also required for androgen receptor activation in hormone sensitive cells. More recently Ras has been shown to work synergistically with other pathways to promote prostate tumorigenesis. We review the multiple lines of evidence implicating Ras as therapeutic target in androgen dependent and independent prostate cancer.
Keywords: Androgen receptor, growth factor, signal transduction, anti-androgen.
Current Cancer Drug Targets
Title:RAS Pathways in Prostate Cancer - Mediators of Hormone Resistance?
Volume: 10 Issue: 8
Author(s): H. C. Whitaker and D. E. Neal
Affiliation:
Keywords: Androgen receptor, growth factor, signal transduction, anti-androgen.
Abstract: Although not frequently mutated in prostate cancer Ras isoforms play a pivotal role in multiple pathways that have been implicated in prostate cancer progression to androgen independence. These have included growth factor and cytokine induced activation of the androgen receptor and its coregulators by post translational modification. Current evidence suggests that Ras is also required for androgen receptor activation in hormone sensitive cells. More recently Ras has been shown to work synergistically with other pathways to promote prostate tumorigenesis. We review the multiple lines of evidence implicating Ras as therapeutic target in androgen dependent and independent prostate cancer.
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Cite this article as:
C. Whitaker H. and E. Neal D., RAS Pathways in Prostate Cancer - Mediators of Hormone Resistance?, Current Cancer Drug Targets 2010; 10 (8) . https://dx.doi.org/10.2174/156800910793358005
DOI https://dx.doi.org/10.2174/156800910793358005 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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