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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Combined Patch Containing Salicylic Acid and Nicotinamide: Role of Drug Interaction

Author(s): Cristina Padula, Chiara Ferretti, Sara Nicoli and Patrizia Santi

Volume 7, Issue 5, 2010

Page: [415 - 420] Pages: 6

DOI: 10.2174/156720110793566218

Price: $65

Abstract

The aim of the present study was to formulate a combined patch containing salicylic (SA) acid and nicotinamide (NA), useful for the treatment of mild acne, and to verify their mutual effect on drug permeation and skin retention. The performance of the patch was tested in vitro in permeation experiments using pig ear skin as barrier. To better understand the data obtained from the film, permeation from solutions and isopropyl myristate/water partition coefficient were also determined. The results obtained in the present work suggest a mutual influence of NA and SA on their permeation across the skin from an innovative transdermal film. The partition coefficient obtained when the two molecules were simultaneously present was typically lower than the respective value obtained with NA and SA alone.

Keywords: Salicylic acid, nicotinamide, dermal, patch, acne


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