Abstract
Plant-derived natural products have been an important source of several clinically useful anti-cancer agents. Plants continue to play a major role in drug discovery as evidenced by the number of promising new agents in clinical development based on selective activity against cancer-related molecular targets. Due to improvements in tumor targeting technology, some agents which failed in earlier clinical studies are also stimulating renewed interest. We wish to draw the attention of readers to the rapidly evolving recognition that a significant number of natural product drugs/leads are possibly produced by endophytic fungi and microbes residing in the plant tissues. We consider that this area of natural product research should be expanded significantly.
Keywords: Plant-derived natural products, anticancer, antitumor, targeted agents, endophytes, Natural Products, Anticancer Drug, cancer-related molecular targets, natural product drugs, endophytic fungi, taxanes, camptothecins, bioactive compounds, semi-synthetic, synthetic analogs, tumor cells, competitive inhibition, Vinca Alkaloids, vinorelbine, cancers, leukemias, lymphomas, breast and lung cancers, Kaposi's sarcoma, Epi-Podophyllotoxins, podophyllotoxin, etoposide, teniposide, colorectal cancers, Plant-derived Clinical Agents, homoharringtonine (HHT), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), complete hematologic remission (CHR), elliptinium (Celiptium), Combretastatins, combretistatin A4 phosphate (CA4), flavopriidol (Alvocidib), rohitukine, olomucine, roscovitine, purvalanol A purvalanol B, Ingenol-3-Angelate, Triptolide, maytansine, Bruceantin, Indirubins, 6-bromoindirubin, 6-bromoindirubin oxime, Silvestrol, epi-Silvestrol, withacnistin A, Emericellamide A
Current Organic Chemistry
Title: Plant Natural Products in Anticancer Drug Discovery
Volume: 14 Issue: 16
Author(s): Paul G. Grothaus, Gordon M. Cragg and David J. Newman
Affiliation:
Keywords: Plant-derived natural products, anticancer, antitumor, targeted agents, endophytes, Natural Products, Anticancer Drug, cancer-related molecular targets, natural product drugs, endophytic fungi, taxanes, camptothecins, bioactive compounds, semi-synthetic, synthetic analogs, tumor cells, competitive inhibition, Vinca Alkaloids, vinorelbine, cancers, leukemias, lymphomas, breast and lung cancers, Kaposi's sarcoma, Epi-Podophyllotoxins, podophyllotoxin, etoposide, teniposide, colorectal cancers, Plant-derived Clinical Agents, homoharringtonine (HHT), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), complete hematologic remission (CHR), elliptinium (Celiptium), Combretastatins, combretistatin A4 phosphate (CA4), flavopriidol (Alvocidib), rohitukine, olomucine, roscovitine, purvalanol A purvalanol B, Ingenol-3-Angelate, Triptolide, maytansine, Bruceantin, Indirubins, 6-bromoindirubin, 6-bromoindirubin oxime, Silvestrol, epi-Silvestrol, withacnistin A, Emericellamide A
Abstract: Plant-derived natural products have been an important source of several clinically useful anti-cancer agents. Plants continue to play a major role in drug discovery as evidenced by the number of promising new agents in clinical development based on selective activity against cancer-related molecular targets. Due to improvements in tumor targeting technology, some agents which failed in earlier clinical studies are also stimulating renewed interest. We wish to draw the attention of readers to the rapidly evolving recognition that a significant number of natural product drugs/leads are possibly produced by endophytic fungi and microbes residing in the plant tissues. We consider that this area of natural product research should be expanded significantly.
Export Options
About this article
Cite this article as:
G. Grothaus Paul, M. Cragg Gordon and J. Newman David, Plant Natural Products in Anticancer Drug Discovery, Current Organic Chemistry 2010; 14 (16) . https://dx.doi.org/10.2174/138527210792927708
DOI https://dx.doi.org/10.2174/138527210792927708 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Potential Application of Biomaterials in Cardiac Stem Cell Therapy
Current Medicinal Chemistry An Update on Peptide Drugs for Voltage-Gated Calcium Channels
Recent Patents on CNS Drug Discovery (Discontinued) Defensin Participation in Innate and Adaptive Immunity
Current Pharmaceutical Design New Approach to Cancer Therapy: The Application of Signal Transduction to Anti-Cancer Drug
Current Medicinal Chemistry - Anti-Cancer Agents Cerebral Artery Signal Transduction Mechanisms: Developmental Changes in Dynamics and Ca<sup>2+</sup> Sensitivity
Current Vascular Pharmacology Infection, Infectious Agents and Vascular Disease
Reviews on Recent Clinical Trials Role of Thymidine Phosphorylase in Biomodulation of Fluoropyrimidines
Current Pharmaceutical Biotechnology An Agathokakological Tale of Δ<sup>9</sup>-THC: Exploration of Possible Biological Targets
Current Drug Targets Muscarinic Receptors as Targets for Metronomic Therapy in Breast Cancer
Current Pharmaceutical Design Role of Radiopharmaceuticals in Development of Inhaled Drugs
Current Pharmaceutical Design Power from the Garden: Plant Compounds as Inhibitors of the Hallmarks of Cancer
Current Medicinal Chemistry Non-Surgical Treatment Options for Symptomatic Uterine Leiomyomas
Current Women`s Health Reviews Ceramidases in Hematological Malignancies: Senseless or Neglected Target?
Anti-Cancer Agents in Medicinal Chemistry Recent Advances of Kinesin Motor Inhibitors and their Clinical Progress
Reviews on Recent Clinical Trials Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers
Current Drug Metabolism Nanoparticle Based Delivery of Protease Inhibitors to Cancer Cells
Current Medicinal Chemistry Drug Acyl Glucuronides: Reactivity and Analytical Implication
Current Pharmaceutical Analysis Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?
Current Drug Targets Nanomedicine to Deal With Cancer Cell Biology in Multi-Drug Resistance
Mini-Reviews in Medicinal Chemistry Anatomical, Biochemical and Physiological Considerations of the Colon in Design and Development of Novel Drug Delivery Systems
Current Drug Delivery