SnoN: Bridging Neurobiology and Cancer Biology

I.      Pot; Y.      Ikeuchi; A.      Bonni; S.      Bonni

Abstract

The transcriptional regulator SnoN has been the subject of growing interest due to its diverse functions in normal and pathological settings. A large body of evidence has established a fundamental role for SnoN as a modulator of signaling and responses by the transforming growth beta (TGFβ) family of cytokines, though how SnoN regulates TGFβ responses remains incompletely understood. In accordance with the critical and complex roles of TGFβ in tumorigenesis and metastasis, SnoN may act as a tumor promoter or suppressor depending on the stage and type of cancer. Beyond its role in cancer, SnoN has also been implicated in the control of axon morphogenesis in postmitotic neurons in the mammalian brain. Remarkably, signaling pathways that control SnoN functions in the divergent cycling cells and postmitotic neurons appear to be conserved. Identification of novel SnoN regulatory and effector mechanisms holds the promise of advances at the interface of cancer biology and neurobiology.

Keywords: SnoN, ING2, Ccd1, TGF-β, Smad, signaling, transcription control, cell cycle, axonal growth, cancer, TGF-b, Homeostasis, Histone deacetylase, Plant homeodomain, Tripartite complex, Oncogene, Tumorigenesis, Barrett's esophagus, Ski, Neurobiology, Metastasis