Abstract
Fast chiral liquid chromatographic methods are developed for the separation of bicalutamide and thalidomide enantiomers in bulk drug samples in an elution time of about 15 min. The chromatographic separation was carried out on various solvents using an amylose 3,5-dimethylphenylcarbamate immobilized onto silica gel (Chiralpak®-IA). The resolution (Rs) between the enantiomers is found to be greater than 1.5 in the developed method. Chiralpak®-IA column played a key role in achieving chromatographic resolution between the enantiomers and also in enhancing chromatographic efficiency. The columns compatability to non standard chromatographic solvents is checked and found suitable.
Keywords: Bicalutamide, Thalidomide, Chiralpak®-IA, Enantiomeric separation, Non-Steroidal Anti-Androgen, Sedative-Hypnotic, Multiple Myeloma, Pharmacokinetic, HPLC, Limit of Quantification, Precision, Robustness
Current Pharmaceutical Analysis
Title: Novel Chiral LC Methods for the Enantiomeric Separation of Bicalutamide and Thalidomide on Amylose Based Immobilized CSP
Volume: 7 Issue: 1
Author(s): I. V. Soma Raju, P. Raghuram and J. Sriramulu
Affiliation:
Keywords: Bicalutamide, Thalidomide, Chiralpak®-IA, Enantiomeric separation, Non-Steroidal Anti-Androgen, Sedative-Hypnotic, Multiple Myeloma, Pharmacokinetic, HPLC, Limit of Quantification, Precision, Robustness
Abstract: Fast chiral liquid chromatographic methods are developed for the separation of bicalutamide and thalidomide enantiomers in bulk drug samples in an elution time of about 15 min. The chromatographic separation was carried out on various solvents using an amylose 3,5-dimethylphenylcarbamate immobilized onto silica gel (Chiralpak®-IA). The resolution (Rs) between the enantiomers is found to be greater than 1.5 in the developed method. Chiralpak®-IA column played a key role in achieving chromatographic resolution between the enantiomers and also in enhancing chromatographic efficiency. The columns compatability to non standard chromatographic solvents is checked and found suitable.
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V. Soma Raju I., Raghuram P. and Sriramulu J., Novel Chiral LC Methods for the Enantiomeric Separation of Bicalutamide and Thalidomide on Amylose Based Immobilized CSP, Current Pharmaceutical Analysis 2011; 7 (1) . https://dx.doi.org/10.2174/157341211794708758
DOI https://dx.doi.org/10.2174/157341211794708758 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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