Abstract
Estrogen-dependent breast cancer (EDBC) is a kind of common malignant tumor in postmenopausal women with growing tendency in recent years. Aromatase (AR) is the key enzyme responsible for estrogen biosynthesis and has been considered as an important target for designing inhibitors as potent therapeutic agents for EDBC. AR inhibitors (AIs) are divided into steroidal and nonsteroidal compounds, and the latter shows high inhibitory potency against AR. This review summarizes recent advancement in nonsteroidal AIs.
Keywords: Estrogen-dependent breast cancer, postmenopausal women, aromatase, aromatase inhibitors, nonsteroida, Nonsteroidal Aromatase Inhibitors, Aromatase (AR), therapeutic agents, nonsteroidal, peripheral tissues, endocrine therapy, multienzymatic complex, granulosa, luteal cells, glycosylated cytochrome P450, C19 androgenic, ovarian granulosa cells, prostaglandin E2 (PGE2), cellular transformation, oncogenesis, inflammatory cytokines, (EGFR) HER-2, COX-2, PGE2, CYP19, letrozole, anastrozole, tolerability, mammary tumors, long-term tamoxifen treatment, traditional Chinese medicine, flavanone, liquiritigenin, inhibitory potency, pyridinecontaining (E)-isomer, aminoglutethimide, Isoflavones, prostate cancer, imidazolic, Dual Aromatase-Sulfatase Inhibitors, Estrone 3-sulfamate (EMATE), YM511, Nimesulide Analogues, breast adipose stromal, celecoxib, Estrogen receptor
Current Medicinal Chemistry
Title: Recent Advancement in Nonsteroidal Aromatase Inhibitors for Treatment of Estrogen-Dependent Breast Cancer
Volume: 17 Issue: 30
Author(s): J. Jiao, H. Xiang and Q. Liao
Affiliation:
Keywords: Estrogen-dependent breast cancer, postmenopausal women, aromatase, aromatase inhibitors, nonsteroida, Nonsteroidal Aromatase Inhibitors, Aromatase (AR), therapeutic agents, nonsteroidal, peripheral tissues, endocrine therapy, multienzymatic complex, granulosa, luteal cells, glycosylated cytochrome P450, C19 androgenic, ovarian granulosa cells, prostaglandin E2 (PGE2), cellular transformation, oncogenesis, inflammatory cytokines, (EGFR) HER-2, COX-2, PGE2, CYP19, letrozole, anastrozole, tolerability, mammary tumors, long-term tamoxifen treatment, traditional Chinese medicine, flavanone, liquiritigenin, inhibitory potency, pyridinecontaining (E)-isomer, aminoglutethimide, Isoflavones, prostate cancer, imidazolic, Dual Aromatase-Sulfatase Inhibitors, Estrone 3-sulfamate (EMATE), YM511, Nimesulide Analogues, breast adipose stromal, celecoxib, Estrogen receptor
Abstract: Estrogen-dependent breast cancer (EDBC) is a kind of common malignant tumor in postmenopausal women with growing tendency in recent years. Aromatase (AR) is the key enzyme responsible for estrogen biosynthesis and has been considered as an important target for designing inhibitors as potent therapeutic agents for EDBC. AR inhibitors (AIs) are divided into steroidal and nonsteroidal compounds, and the latter shows high inhibitory potency against AR. This review summarizes recent advancement in nonsteroidal AIs.
Export Options
About this article
Cite this article as:
Jiao J., Xiang H. and Liao Q., Recent Advancement in Nonsteroidal Aromatase Inhibitors for Treatment of Estrogen-Dependent Breast Cancer, Current Medicinal Chemistry 2010; 17 (30) . https://dx.doi.org/10.2174/092986710792927877
DOI https://dx.doi.org/10.2174/092986710792927877 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Understanding Prostate Cancer Cells Metabolome: A Spectroscopic Approach
Current Metabolomics Chromogranin A in Tumors: More Than a Marker for Diagnosis and Prognosis
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Osteonecrosis of the Jaw and Angiogenesis inhibitors: A Revival of a Rare but Serous Side Effect
Current Medicinal Chemistry Th1-mediated Pathology in Mouse Models of Human Disease is Ameliorated by Concurrent Th2 Responses to Parasite Antigens
Current Topics in Medicinal Chemistry Emerging Technologies, Recent Developments, and Novel Applications for Drug Metabolite Identification
Current Drug Metabolism In the Crosshairs: NF-κB Targets the JNK Signaling Cascade
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Recent Clinical Aspects of Hyperprolactinemia Induced by Antipsychotics
Reviews on Recent Clinical Trials Histone Deacetylase Inhibitors in Tumor Immunotherapy
Current Medicinal Chemistry Natural Substances in the Treatment of Cystic Fibrosis
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Recombinant Adeno-associated Virus 9-mediated Expression of Kallistatin Suppresses Lung Tumor Growth in Mice
Current Gene Therapy Network Pharmacology of Ayurveda Formulation <i>Triphala</i> with Special Reference to Anti-Cancer Property
Combinatorial Chemistry & High Throughput Screening Novel Superactive Leptin Antagonists and their Potential Therapeutic Applications
Current Pharmaceutical Design Revisiting Non-Cancer Drugs for Cancer Therapy
Current Topics in Medicinal Chemistry BDNF/NF-κB Signaling in the Neurobiology of Depression
Current Pharmaceutical Design Neurokinin-1 Receptor Antagonists as Anticancer Drugs
Letters in Drug Design & Discovery Polymorphisms in miRNAs Gene (146a, 149, 196a) and Susceptibility to ARV-associated Hepatotoxicity
Current Genomics Computational Study of the Binding Modes of Diverse DPN Analogues on Estrogen Receptors (ER) and the Biological Evaluation of a New Potential Antiestrogenic Ligand
Anti-Cancer Agents in Medicinal Chemistry Targeting Heat Shock Proteins in Tauopathies
Current Alzheimer Research Research Advances in the Use of Histone Deacetylase Inhibitors for Epigenetic Targeting of Cancer
Current Topics in Medicinal Chemistry <i>In Vivo</i> Tracking of Novel SPIO-Molday ION Rhodamine-B™-Labeled Human Bone Marrow-Derived Mesenchymal Stem Cells After Lentivirus- Mediated COX-2 Silencing: A Preliminary Study
Current Gene Therapy