Abstract
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, and its prevalence is rising in parallel with worldwide increases in obesity and type 2 diabetes. However, the nature of this relationship remains debatable. In particular, it is unclear whether insulin resistance causes NAFLD or hepatic steatosis per se reduces insulin sensitivity. This review will examine data from recent studies on the link between insulin resistance and NAFLD, focusing on studies that have attempted to dissociate fatty liver and hepatic insulin resistance.
Keywords: Non-alcoholic fatty liver disease, Insulin resistance, Triglycerides, Free fatty acids, Steatosis, Mitochondrial dysfunction, Hepatic Fat, Hepatic Steatosis, Pathogenesis, Fat Accumulation, hyperinsulinemia, Lipid Dynamics, Intracellular Signaling, Hepatic Insulin Resistance, methionine and choline deficiency (MCD), very low density lipoprotein (VLDL), insulin receptor substrate (IRS), nuclear factor-kappaB (NFκB)
Current Diabetes Reviews
Title: Interrelationships between Hepatic Fat and Insulin Resistance in Non- Alcoholic Fatty Liver Disease
Volume: 6 Issue: 5
Author(s): Khalida A. Lockman and Moffat J. Nyirenda
Affiliation:
Keywords: Non-alcoholic fatty liver disease, Insulin resistance, Triglycerides, Free fatty acids, Steatosis, Mitochondrial dysfunction, Hepatic Fat, Hepatic Steatosis, Pathogenesis, Fat Accumulation, hyperinsulinemia, Lipid Dynamics, Intracellular Signaling, Hepatic Insulin Resistance, methionine and choline deficiency (MCD), very low density lipoprotein (VLDL), insulin receptor substrate (IRS), nuclear factor-kappaB (NFκB)
Abstract: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, and its prevalence is rising in parallel with worldwide increases in obesity and type 2 diabetes. However, the nature of this relationship remains debatable. In particular, it is unclear whether insulin resistance causes NAFLD or hepatic steatosis per se reduces insulin sensitivity. This review will examine data from recent studies on the link between insulin resistance and NAFLD, focusing on studies that have attempted to dissociate fatty liver and hepatic insulin resistance.
Export Options
About this article
Cite this article as:
A. Lockman Khalida and J. Nyirenda Moffat, Interrelationships between Hepatic Fat and Insulin Resistance in Non- Alcoholic Fatty Liver Disease, Current Diabetes Reviews 2010; 6 (5) . https://dx.doi.org/10.2174/157339910793360879
DOI https://dx.doi.org/10.2174/157339910793360879 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
P-glycoprotein Inhibition: The Past, the Present and the Future
Current Drug Metabolism <i>Uncaria tomentosa</i> (Willd. ex Schult.): Focus on Nutraceutical Aspects
Current Bioactive Compounds Specific Immune Intervention with Monoclonal Antibodies for the Treatment of Multiple Sclerosis
Current Medicinal Chemistry Network Insights into the Genes Regulated by Hepatocyte Nuclear Factor 4 in Response to Drug Induced Perturbations: A Review
Current Drug Discovery Technologies Chemical Constituents and Pharmacological Activities of Stellera chamaejasme
Current Pharmaceutical Design Applications of the Rare Earth Elements in Cancer Imaging and Therapy
Current Nanoscience Survivin Modulators: An Updated Patent Review (2011 - 2015)
Recent Patents on Anti-Cancer Drug Discovery Synthesis of Medicinally Privileged Heterocycles through Dielectric Heating
Current Medicinal Chemistry Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses
Recent Patents on Anti-Cancer Drug Discovery Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare
Current Pharmaceutical Biotechnology α-Halogenoacrylic Derivatives of Antitumor Agents
Mini-Reviews in Medicinal Chemistry Isoform Characterisation, Heterologous Expression and Functional Analysis of Two Lectins from Vatairea macrocarpa
Protein & Peptide Letters Are the Antioxidant Properties of Carvedilol Important for the Protection of Cardiac Mitochondria?
Current Vascular Pharmacology Development Course and an Application Strategy for Induced Pluripotent Stem Cells in Regenerative Medicine
Current Stem Cell Research & Therapy A New Approach for β-cyclodextrin Conjugated Drug Delivery System in Cancer Therapy
Current Drug Delivery The Role of B Cell Receptor Stimulation in CLL Pathogenesis
Current Pharmaceutical Design The Potential Anti-Tumorigenic and Anti-Metastatic Side of the Proprotein Convertases Inhibitors
Recent Patents on Anti-Cancer Drug Discovery Cancer Cell Reprogramming: Stem Cell Differentiation Stage Factors and An Agent Based Model to Optimize Cancer Treatment
Current Pharmaceutical Biotechnology T-Cell Zeta Chain Expression, Phosphorylation and Degradation and their Role in T-Cell Signal Transduction and Immune Response Regulation in Health And Disease
Current Signal Transduction Therapy Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting
Current Drug Targets