Chloroquine Resistance: Proposed Mechanisms and Countermeasures

Author(s): Eric Guantai, Kelly Chibale.

Journal Name: Current Drug Delivery

Volume 7 , Issue 4 , 2010

Abstract:

Malaria has been, and remains, one of the biggest global health concerns as far as infectious diseases are concerned, with yearly incidence and mortality figures running into millions. One of the major drawbacks to the control of this disease has been the emergence of drug resistant strains of the causative agent, which limits the successful use of many clinically available antimalarial drugs. This review discusses chloroquine resistance; it highlights some of the proposed molecular mechanisms of chloroquine resistance, but dwells more on efforts at reversing chloroquine resistance and the concept of chloroquine resistance-reversal agents.

Keywords: Chloroquine resistance, chloroquine resistance-reversal agents, chloroquine resistance-reversal pharmacophore, reversed-chloroquines

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2010
Page: [312 - 323]
Pages: 12
DOI: 10.2174/156720110793360577
Price: $58

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