Abstract
The noninvasive detection of cell death has significant diagnostic values. Molecular events in apoptosis and necrosis are a source of valuable surrogate markers for the detection of cell death. Two classes of imaging agents are being developed for imaging caspase activities and redistribution of membrane phospholipids, respectively. The current review looks at the molecular recognition mechanisms of existing and emerging agents in the physiological context of the surrogate markers. The imaging of caspase activities using substrate-derived agents has the advantage of high selectivity and can potentially allow the dissection of individual apoptotic pathways in vivo. The detection of membrane phospholipid redistribution using extracellular agents has the advantage of high target density and accessibility. The strength and limitations of each approach are discussed. Overall, in order to develop appropriate imaging techniques, it is important to understand the interactions between the agent and surogate markers on a molecular as well as physiological level. Such information is vital for fully appreciating the potential utilities of an imaging strategy.
Current Pharmaceutical Biotechnology
Title: Molecular Recognition Mechanisms for Detecting Cell Death In Vivo
Volume: 11 Issue: 6
Author(s): Ming Zhao
Affiliation:
Keywords: Apoptosis, Necrosis, Imaging, Probe
Abstract: The noninvasive detection of cell death has significant diagnostic values. Molecular events in apoptosis and necrosis are a source of valuable surrogate markers for the detection of cell death. Two classes of imaging agents are being developed for imaging caspase activities and redistribution of membrane phospholipids, respectively. The current review looks at the molecular recognition mechanisms of existing and emerging agents in the physiological context of the surrogate markers. The imaging of caspase activities using substrate-derived agents has the advantage of high selectivity and can potentially allow the dissection of individual apoptotic pathways in vivo. The detection of membrane phospholipid redistribution using extracellular agents has the advantage of high target density and accessibility. The strength and limitations of each approach are discussed. Overall, in order to develop appropriate imaging techniques, it is important to understand the interactions between the agent and surogate markers on a molecular as well as physiological level. Such information is vital for fully appreciating the potential utilities of an imaging strategy.
Export Options
About this article
Cite this article as:
Zhao Ming, Molecular Recognition Mechanisms for Detecting Cell Death In Vivo, Current Pharmaceutical Biotechnology 2010; 11 (6) . https://dx.doi.org/10.2174/138920110792246591
DOI https://dx.doi.org/10.2174/138920110792246591 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Highlights on Medical Treatment of Uterine Fibroids
Current Pharmaceutical Design Nuclear Export Mediated Regulation of MicroRNAs: Potential Target for Drug Intervention
Current Drug Targets New Molecular Targets in the Treatment of NSCLC
Current Pharmaceutical Design Multicolor-FISH Approaches for the Characterization of Human Chromosomes in Clinical Genetics and Tumor Cytogenetics
Current Genomics New Molecular and Cellular Targets for Chemoprevention and Treatment of Skin Tumors by Plant Polyphenols: A Critical Review
Current Medicinal Chemistry Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo
CNS & Neurological Disorders - Drug Targets Cancer Stem Cells in Solid and Liquid Tissues of Breast Cancer Patients: Characterization and Therapeutic Perspectives
Current Cancer Drug Targets Dry Eye Disease: Present Challenges in the Management and Future Trends
Current Pharmaceutical Design Targeting of Peptide Cytotoxins to LHRH Receptors For Treatment of Cancer
Current Drug Targets Glioblastoma Tumor Initiating Cells: Therapeutic Strategies Targeting Apoptosis and MicroRNA Pathways
Current Molecular Medicine Structure and Function of the Epstein-Barr Virus Transcription Factor, EBNA 3C
Current Protein & Peptide Science <i>In vitro</i> and <i>in vivo</i> Evaluation of 17-phenylpropylamine/phenoxyethylamine- 17-demethoxygeldanamycins as Potent Hsp90 Inhibitors
Medicinal Chemistry Inhibition of HIV-1 Entry into Cells
Recent Patents on Anti-Infective Drug Discovery Clinical Experience with Thalidomide and Lenalidomide in Multiple Myeloma
Current Cancer Drug Targets Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives
Letters in Drug Design & Discovery Thalidomide: An Overview of its Pharmacological Mechanisms of Action
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2-Substituted-5-Nitroheterocycles: In Vitro Anti-Helicobacter pylori Activity and Structure-Activity Relationship Study
Medicinal Chemistry Targeting Transcription Factor Binding to DNA by Competing with DNA Binders as an Approach for Controlling Gene Expression
Current Topics in Medicinal Chemistry Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders
Current Genomics Life and Death of Leukemic Cells Under Bcr-Abl Signaling Control
Current Cancer Therapy Reviews