Abstract
Switching from the concept of substance or alcohol dependence to that of addiction has profoundly modified our ways of approaching, treating and organizing the care of this disease. This more complex and subtle approach gives less importance to the substance and its effects and focuses more on the initiation of pathological behavior. It is important to keep in mind that the addictive process associates a substance (more or less addictive), an individual (more or less vulnerable) and an environment (more or less condoning). Today, it is no longer possible to consider that a drug acts on only one receptor or one system. Current understanding of inner regulation mechanisms integrates the interactions between the various stimulated brain pathways. Addiction treatments which should benefit from advances in genetics, neuropsychology and neuroimaging could be increasingly individualized in the years to come. The “addictology” approach has triggered thinking about other therapeutic approaches such as modification of therapeutic objectives toward “risk reductions” or applying this model to behavioral addictions (food, sex, sport, gaming…)
Keywords: Addiction, individual vulnerability, behavioural, environment, DSM-V, neuropsychology, neuroimaging, addictology, vulnerable, polysubstance, epigenetic, psychology, acetylcholine, neurokinine, glutamate, medications, diagnostic, pertinent, polymorphisms
Current Pharmaceutical Design
Title: From Substance Dependence to Addiction: Impact of a Conceptual Shift on Therapeutic Approaches?
Volume: 17 Issue: 14
Author(s): Michel Reynaud and Laurent Karila
Affiliation:
Keywords: Addiction, individual vulnerability, behavioural, environment, DSM-V, neuropsychology, neuroimaging, addictology, vulnerable, polysubstance, epigenetic, psychology, acetylcholine, neurokinine, glutamate, medications, diagnostic, pertinent, polymorphisms
Abstract: Switching from the concept of substance or alcohol dependence to that of addiction has profoundly modified our ways of approaching, treating and organizing the care of this disease. This more complex and subtle approach gives less importance to the substance and its effects and focuses more on the initiation of pathological behavior. It is important to keep in mind that the addictive process associates a substance (more or less addictive), an individual (more or less vulnerable) and an environment (more or less condoning). Today, it is no longer possible to consider that a drug acts on only one receptor or one system. Current understanding of inner regulation mechanisms integrates the interactions between the various stimulated brain pathways. Addiction treatments which should benefit from advances in genetics, neuropsychology and neuroimaging could be increasingly individualized in the years to come. The “addictology” approach has triggered thinking about other therapeutic approaches such as modification of therapeutic objectives toward “risk reductions” or applying this model to behavioral addictions (food, sex, sport, gaming…)
Export Options
About this article
Cite this article as:
Reynaud Michel and Karila Laurent, From Substance Dependence to Addiction: Impact of a Conceptual Shift on Therapeutic Approaches?, Current Pharmaceutical Design 2011; 17 (14) . https://dx.doi.org/10.2174/138161211796150800
DOI https://dx.doi.org/10.2174/138161211796150800 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis,
Mechanisms and Potential Treatments
Current Pharmaceutical Design PUFA for Human Health: Diet or Supplementation?
Current Pharmaceutical Design Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug Delivery
Current Medicinal Chemistry Characteristics of Insulin-degrading Enzyme in Alzheimer's Disease: A Meta-Analysis
Current Alzheimer Research May Exercise Prevent Addiction?
Current Neuropharmacology Societal and Cultural Attitudes to Gout: An Important Consideration in the Successful Management of Gout among Maori in Aotearoa New Zealand
Current Rheumatology Reviews Inflammation and Parkinsons Disease
Current Drug Targets - Inflammation & Allergy Copper Binding Extrinsic to the Octarepeat Region in the Prion Protein
Current Protein & Peptide Science Excitotoxic Mechanisms in Non-Motor Dysfunctions and Levodopa- Induced Dyskinesia in Parkinson's Disease: The Role of the Interaction Between the Dopaminergic and the Kynurenine System
Current Medicinal Chemistry Meet Our Editorial Board Member
Current Alzheimer Research Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies
Current Drug Targets Deciphering the Neuroprotective Role of Glucagon-like Peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions
Current Protein & Peptide Science Pharmacological and Biological Activities of Benzazepines: An Overview
Current Bioactive Compounds Disease Outcome, Alexithymia and Depression are Differently Associated with Serum IL-18 Levels in Acute Stroke
Current Neurovascular Research Is There A Pulse Wave Encephalopathy Component To Multiple Sclerosis?
Current Neurovascular Research Off-Label Drug Use in Paediatrics: A World-Wide Problem
Current Drug Targets Female Infertility and Antioxidants
Current Women`s Health Reviews Rheumatic Manifestations in Malignancy
Current Rheumatology Reviews Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches
CNS & Neurological Disorders - Drug Targets Diagnostic Boundaries of Autism Disorder Vs Pervasive Developmental Disorder Nos Comparative Observational Study and Literature Review
Current Clinical Pharmacology