Abstract
In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4 10-9M and LOQ 2.4 10-8M), followed by CF, CEF and DCF. This is in accordance with the strength of their adsorption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.
Keywords: Methoxyimino cephalosporins, reduction, adsorption, AdSDPV determination, urine
Combinatorial Chemistry & High Throughput Screening
Title: Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples
Volume: 13 Issue: 8
Author(s): Mara M. Aleksic and Vera Kapetanovic
Affiliation:
Keywords: Methoxyimino cephalosporins, reduction, adsorption, AdSDPV determination, urine
Abstract: In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4 10-9M and LOQ 2.4 10-8M), followed by CF, CEF and DCF. This is in accordance with the strength of their adsorption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.
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Cite this article as:
M. Aleksic Mara and Kapetanovic Vera, Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples, Combinatorial Chemistry & High Throughput Screening 2010; 13 (8) . https://dx.doi.org/10.2174/138620710791920310
DOI https://dx.doi.org/10.2174/138620710791920310 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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