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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Spiro Isoxazolines via Nitrile Oxide 1,3-Dipolar Cycloaddition Reactions

Author(s): G. Paul Savage

Volume 14, Issue 14, 2010

Page: [1478 - 1499] Pages: 22

DOI: 10.2174/138527210791616812

Price: $65

Abstract

The 1,3-dipolar cycloaddition reaction of nitrile oxides with carbon dipolarophiles is a versatile and powerful synthetic method to prepare isoxazolines. In particular nitrile oxide cycloaddition reactions with exocyclic methylene or alkylidene compounds generally proceed regioselectively leading to spiro heterocyclic compounds. This review deals with progress in the field of nitrile oxide cycloaddition chemistry for the synthesis of spiro isoxazolines.

Keywords: Nitrile oxide, dipolar cycloaddition, heterocycle, spiro, exocyclic methylene, isoxazoline


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