Abstract
A simple, reliable and selective differential pulse (DP) and square wave (SW) voltammetric methods at glassy carbon (GC) and boron-doped diamond (BDD) electrodes of lornoxicam in pharmaceutical dosage form and in spiked human serum samples have been developed and evaluated. The possible oxidation mechanism was discussed. The voltammetric study of the model compounds allowed elucidating the possible oxidation mechanism of lornoxicam. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate were investigated. The oxidation of lornoxicam gave a single and irreversible peak at both electrodes. The process was found diffusion controlled. For glassy carbon electrode, the linearity of the calibration curve was obtained in the range of 4×10-7 M to 2×10-5 M for DPV method and 4×10-7 M to 4×10-5 M for SWV method in 0,1 M sulphuric acid solutions. Using boron-doped diamond electrode, the plot of the calibration curve was linear between 6×10-7 M and 1×10-4 M for both voltammetric methods in pH 2 BR buffer. The repeatability, reproducibility, precision and accuracy of the proposed methods were investigated.
Keywords: Lornoxicam, voltammetry, boron-doped diamond electrode, glassy carbon electrode, pharmaceutical dosage form, serum
Combinatorial Chemistry & High Throughput Screening
Title: Applications of Carbon Based Electrodes for Voltammetric Determination of Lornoxicam in Pharmaceutical Dosage Form and Human Serum
Volume: 13 Issue: 7
Author(s): Burcin Bozal and Bengi Uslu
Affiliation:
Keywords: Lornoxicam, voltammetry, boron-doped diamond electrode, glassy carbon electrode, pharmaceutical dosage form, serum
Abstract: A simple, reliable and selective differential pulse (DP) and square wave (SW) voltammetric methods at glassy carbon (GC) and boron-doped diamond (BDD) electrodes of lornoxicam in pharmaceutical dosage form and in spiked human serum samples have been developed and evaluated. The possible oxidation mechanism was discussed. The voltammetric study of the model compounds allowed elucidating the possible oxidation mechanism of lornoxicam. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate were investigated. The oxidation of lornoxicam gave a single and irreversible peak at both electrodes. The process was found diffusion controlled. For glassy carbon electrode, the linearity of the calibration curve was obtained in the range of 4×10-7 M to 2×10-5 M for DPV method and 4×10-7 M to 4×10-5 M for SWV method in 0,1 M sulphuric acid solutions. Using boron-doped diamond electrode, the plot of the calibration curve was linear between 6×10-7 M and 1×10-4 M for both voltammetric methods in pH 2 BR buffer. The repeatability, reproducibility, precision and accuracy of the proposed methods were investigated.
Export Options
About this article
Cite this article as:
Bozal Burcin and Uslu Bengi, Applications of Carbon Based Electrodes for Voltammetric Determination of Lornoxicam in Pharmaceutical Dosage Form and Human Serum, Combinatorial Chemistry & High Throughput Screening 2010; 13 (7) . https://dx.doi.org/10.2174/1386207311004070599
DOI https://dx.doi.org/10.2174/1386207311004070599 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
Call for Papers in Thematic Issues
Artificial Intelligence Methods for Biomedical, Biochemical and Bioinformatics Problems
Recently, a large number of technologies based on artificial intelligence have been developed and applied to solve a diverse range of problems in the areas of biomedical, biochemical and bioinformatics problems. By utilizing powerful computing resources and massive amounts of data, methods based on artificial intelligence can significantly improve the ...read more
Eco-friendly Agents for Biological Control of Pathogenic Diseases
The discovery of an alternative biological approach to disease management includes work on medicinal products derived from natural sources as a starting point for the development of eco-friendly agents for these diseases and the injuries they cause, as well as reducing human contact with hazardous chemicals and their residues. We ...read more
Emerging trends in diseases mechanisms, noble drug targets and therapeutic strategies: focus on immunological and inflammatory disorders
Recently infectious and inflammatory diseases have been a key concern worldwide due to tremendous morbidity and mortality world Wide. Recent, nCOVID-9 pandemic is a good example for the emerging infectious disease outbreak. The world is facing many emerging and re-emerging diseases out breaks at present however, there is huge lack ...read more
Exploring Spectral Graph Theory in Combinatorial Chemistry
Scope of the Thematic Issue: Combinatorial chemistry involves the synthesis and analysis of a large number of diverse compounds simultaneously. Traditional methods rely on brute force experimentation, which can be time-consuming and resource-intensive. Spectral Graph Theory, a branch of mathematics dealing with the properties of graphs in relation to the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chemokines and their Receptors as Targets for the Treatment of COPD
Current Respiratory Medicine Reviews Advances in the Management of Brain Tumors in Infants
Current Cancer Therapy Reviews New Insights into the Pathogenesis of and Long-Term Risks in Children with Henoch-Schonlein Purpura Nephritis
Current Pediatric Reviews Clinical Application of Lentiviral Vectors – Concepts and Practice
Current Gene Therapy Borderline Personality Disorder and Oxytocin: Review of Clinical Trials and Future Directions
Current Pharmaceutical Design HIV-1 Prophylactic Vaccine Trials in Thailand
Current HIV Research Systemic Autoimmune Manifestations: When Should Underlying Thyroid Autoimmunity be Considered?
Current Rheumatology Reviews Editorial [Hot Topic: New Approaches to Treating Cancer: Medicinal Chemistry and Therapeutic Potential (Guest Editor: David J. Weber)]
Current Topics in Medicinal Chemistry Translation of Basic Research into Clinics: Killer Immunoglobulin-like Receptors Genes in Autoimmune and Infectious Diseases
Current Pharmaceutical Design Estrogen Receptor Alpha: Impact of Ligands on Intracellular Shuttling and Turnover Rate in Breast Cancer Cells
Current Cancer Drug Targets Inflammation, Microenvironment, and the Immune System in Cancer Progression
Current Pharmaceutical Design Programmed Cell Death after Intracerebral Hemorrhage
Current Neuropharmacology Electric cable: cytoskeleton as an electric transmitter for cancer therapy
Current Signal Transduction Therapy Gene Therapy of Cancer Based on Interleukin 12
Current Gene Therapy Conjugative Post-Translational Modifications for Pharmacological Improvement of Therapeutic Proteins
Current Proteomics Innate Immunity in the Pathogenesis of Cholangiopathy: A Recent Update
Inflammation & Allergy - Drug Targets (Discontinued) Cytotoxicity and Anti-inflammatory Activity of Flavonoid Derivatives Targeting NF-kappaB
Recent Patents on Inflammation & Allergy Drug Discovery Ignored Avenues in Alpha-Synuclein Associated Proteopathy
CNS & Neurological Disorders - Drug Targets Acute Myocarditis in Children: An Overview of Treatment and Recent Patents
Recent Patents on Inflammation & Allergy Drug Discovery Selective COX-1 Inhibition: A Therapeutic Target to be Reconsidered
Current Medicinal Chemistry