Abstract
Significant advances have been made in the treatment of rectal cancer. Multidisciplinary management is the preferred approach and offers the best clinical outcome. In locally advanced disease, surgery with total mesorectal excision remains the leading option, but adjuvant treatments are necessary due to local and systemic failure. Even if the preoperative approach is the treatment of choice, chemoradiotherapy may be considered both in preoperative or postoperative setting as it significantly improves local control with lower toxicity rates. Nevertheless, additional drugs are to be incorporated in the combined treatment programs mainly aiming to reduce metastases at distant sites.
Keywords: Rectum, chemotherapy, radiation therapy, association
Current Drug Therapy
Title: Chemoradiotherapy in Rectal Cancer
Volume: 5 Issue: 3
Author(s): Marco Lupattelli and Lorenzo Falcinelli
Affiliation:
Keywords: Rectum, chemotherapy, radiation therapy, association
Abstract: Significant advances have been made in the treatment of rectal cancer. Multidisciplinary management is the preferred approach and offers the best clinical outcome. In locally advanced disease, surgery with total mesorectal excision remains the leading option, but adjuvant treatments are necessary due to local and systemic failure. Even if the preoperative approach is the treatment of choice, chemoradiotherapy may be considered both in preoperative or postoperative setting as it significantly improves local control with lower toxicity rates. Nevertheless, additional drugs are to be incorporated in the combined treatment programs mainly aiming to reduce metastases at distant sites.
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Cite this article as:
Lupattelli Marco and Falcinelli Lorenzo, Chemoradiotherapy in Rectal Cancer, Current Drug Therapy 2010; 5 (3) . https://dx.doi.org/10.2174/157488510791561057
DOI https://dx.doi.org/10.2174/157488510791561057 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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