Indoloquinolines as Scaffolds for Drug Discovery

Title: Indoloquinolines as Scaffolds for Drug Discovery

Volume: 17 Issue: 22

Author(s): J. Lavrado, R. Moreira and A. Paulo

Affiliation:

Keywords: Indoloquinolines, cryptolepine, isocryptolepine, neocryptolepine, isoneocryptolepine, structure-activity relationships (SAR), Cryptolepis sanguinolenta

Abstract: Traditional medicines have contributed greatly over the centuries to the discovery and development of new therapeutic agents and indoloquinoline alkaloids may represent a new class of drug leads. Cryptolepine (5-methyl-5H-indolo[ 3,2-b]quinoline), neocryptolepine (5-methyl-5H-indolo[2,3-b]quinoline), isocryptolepine (5-methyl-5H-indolo[3,2- c]quinoline, extracted from the African medicinal plant Cryptolepis sanguinolenta, and isoneocryptolepine (5-methyl-5H-indolo[ 2,3-c]quinoline), which has never been found in nature, are isomeric tetracyclic compounds of particular interest due to their broad spectrum of biological activities including antiparasitic, antifungal, antibacterial, cytotoxic, antiinflammatory and antihyperglycaemic. As a result, in the last 30 years hundreds of indoloquinoline analogues were synthesized and their biological activities evaluated. In this paper, we present an overview of the potential of indoloquinolines as scaffolds in drug discovery by reviewing the in vitro and in vivo biological activities of natural and synthetic analogues, as well as the proposed mechanisms of action and structure-activity relationships.

Cite this article as:

Lavrado J., Moreira R. and Paulo A., Indoloquinolines as Scaffolds for Drug Discovery, Current Medicinal Chemistry 2010; 17 (22) . https://dx.doi.org/10.2174/092986710791698521