Abstract
The [2+2+1]-cycloaddition of an alkyne, an alkene and carbon monoxide known as Pauson-Khand reaction is a powerful way to install two new functional groups and a cycle into a molecule. The great potential of this reaction has thus far been underestimated in the synthesis of pharmacologically active compounds.
Keywords: Pauson-Khand reaction, drug discovery, Diversity-oriented synthesis, target-oriented synthesis
Current Organic Chemistry
Title: The Pauson-Khand Reaction in the Synthesis of Pharmacologically Active Compounds
Volume: 14 Issue: 11
Author(s): Jorg Habermann
Affiliation:
Keywords: Pauson-Khand reaction, drug discovery, Diversity-oriented synthesis, target-oriented synthesis
Abstract: The [2+2+1]-cycloaddition of an alkyne, an alkene and carbon monoxide known as Pauson-Khand reaction is a powerful way to install two new functional groups and a cycle into a molecule. The great potential of this reaction has thus far been underestimated in the synthesis of pharmacologically active compounds.
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Cite this article as:
Habermann Jorg, The Pauson-Khand Reaction in the Synthesis of Pharmacologically Active Compounds, Current Organic Chemistry 2010; 14 (11) . https://dx.doi.org/10.2174/138527210791317085
DOI https://dx.doi.org/10.2174/138527210791317085 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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