Abstract
This work reviews the neuropharmacology of the vestibular system, with an emphasis on the mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists are confronted with a rapidly changing field in which advances in the knowledge of ionic channel function and synaptic transmission mechanisms have led to the development of new scientific models for the understanding of vestibular dysfunction and its management. In particular, there have been recent advances in our knowledge of the fundamental mechanisms of vestibular system function and drug mechanisms of action. In this work, drugs acting on vestibular system have been grouped into two main categories according to their primary mechanisms of action: those with effects on neurotransmitters and neuromodulator receptors and those that act on voltage-gated ion channels. Particular attention is given in this review to drugs that may provide additional insight into the pathophysiology of vestibular diseases. A critical review of the pharmacology and highlights of the major advances are discussed in each case.
Keywords: Inner ear, Vertigo, Dizziness, Meniere's disease, vestibular nuclei, hair cells, excitatory amino acids
Current Neuropharmacology
Title: Neuropharmacology of Vestibular System Disorders
Volume: 8 Issue: 1
Author(s): Enrique Soto and Rosario Vega
Affiliation:
Keywords: Inner ear, Vertigo, Dizziness, Meniere's disease, vestibular nuclei, hair cells, excitatory amino acids
Abstract: This work reviews the neuropharmacology of the vestibular system, with an emphasis on the mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists are confronted with a rapidly changing field in which advances in the knowledge of ionic channel function and synaptic transmission mechanisms have led to the development of new scientific models for the understanding of vestibular dysfunction and its management. In particular, there have been recent advances in our knowledge of the fundamental mechanisms of vestibular system function and drug mechanisms of action. In this work, drugs acting on vestibular system have been grouped into two main categories according to their primary mechanisms of action: those with effects on neurotransmitters and neuromodulator receptors and those that act on voltage-gated ion channels. Particular attention is given in this review to drugs that may provide additional insight into the pathophysiology of vestibular diseases. A critical review of the pharmacology and highlights of the major advances are discussed in each case.
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Cite this article as:
Soto Enrique and Vega Rosario, Neuropharmacology of Vestibular System Disorders, Current Neuropharmacology 2010; 8 (1) . https://dx.doi.org/10.2174/157015910790909511
DOI https://dx.doi.org/10.2174/157015910790909511 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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