Abstract
Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.
Keywords: PEDF, tumor, growth, metastasis
Current Molecular Medicine
Title: The Role of PEDF in Tumor Growth and Metastasis
Volume: 10 Issue: 3
Author(s): D. Hoshina, R. Abe, S.-I. Yamagishi and H. Shimizu
Affiliation:
Keywords: PEDF, tumor, growth, metastasis
Abstract: Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.
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Cite this article as:
Hoshina D., Abe R., Yamagishi S.-I. and Shimizu H., The Role of PEDF in Tumor Growth and Metastasis, Current Molecular Medicine 2010; 10 (3) . https://dx.doi.org/10.2174/156652410791065327
DOI https://dx.doi.org/10.2174/156652410791065327 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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