Abstract
The renin-angiotensin-aldosterone system plays a key role in the development of hypertension-related target organ damage. Nonetheless, compensatory increases in plasma renin levels that lead to adjustments in angiotensin production and conversion limit the potential benefits of both angiotensin converting enzyme inhibitors and angiotensin receptor blockers. On the other hand, the ONTARGET trial reported that the combination of two renin-angiotensin system inhibitors was associated with more adverse events without an increase in benefit. Aliskiren is a novel direct renin inhibitor with promising results. In this manuscript the current evidence about aliskiren, alone or in combination, is analyzed.
Keywords: Aliskiren, renin inhibition, renin-angiotensin-aldosterone system, arterial hypertension, cardiovascular, heart failure, microalbuminuria
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Aliskiren: A New Drug for an Old Problem
Volume: 8 Issue: 1
Author(s): V. Barrios and C. Escobar
Affiliation:
Keywords: Aliskiren, renin inhibition, renin-angiotensin-aldosterone system, arterial hypertension, cardiovascular, heart failure, microalbuminuria
Abstract: The renin-angiotensin-aldosterone system plays a key role in the development of hypertension-related target organ damage. Nonetheless, compensatory increases in plasma renin levels that lead to adjustments in angiotensin production and conversion limit the potential benefits of both angiotensin converting enzyme inhibitors and angiotensin receptor blockers. On the other hand, the ONTARGET trial reported that the combination of two renin-angiotensin system inhibitors was associated with more adverse events without an increase in benefit. Aliskiren is a novel direct renin inhibitor with promising results. In this manuscript the current evidence about aliskiren, alone or in combination, is analyzed.
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Cite this article as:
Barrios V. and Escobar C., Aliskiren: A New Drug for an Old Problem, Cardiovascular & Hematological Agents in Medicinal Chemistry 2010; 8 (1) . https://dx.doi.org/10.2174/187152510790796174
DOI https://dx.doi.org/10.2174/187152510790796174 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
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