Abstract
The highly conserved heat-shock proteins (HSPs) from mammals and microbial reagents are among the immunogenic proteins. Their expression is induced in response to a wide variety of physiological and environmental insults. Their functions as molecular chaperones allow cells to adapt to gradual changes in their environment and to survive in otherwise lethal conditions. Although the role of HSPs in atherosclerosis remains controversial, HSPs were thought to act as autoantigens, and trigger both cell- and antibody-mediated immune responses. However, HSPs possess immunoregulatory attributes as well and therefore, are being exploited for immunomodulation of atherosclerosis either by the adaptive or innate immune system. This review will focus on a number of HSPs from different families including HSPE, HSPB, DNAJ, HSPD, HSPA, HSPC and HSPH. The role of these HSPs, their protective vs. immunogenic properties with special emphasis on their potential as targets to develop therapeutic agent against atherosclerosis will be discussed.
Keywords: Heat shock protein, atherosclerosis, autoimmune, inflammation, immune response
Current Medicinal Chemistry
Title: The Role of Heat Shock Protein (HSP) in Atherosclerosis: Pathophysiology and Clinical Opportunities
Volume: 17 Issue: 10
Author(s): X. Lu and V. Kakkar
Affiliation:
Keywords: Heat shock protein, atherosclerosis, autoimmune, inflammation, immune response
Abstract: The highly conserved heat-shock proteins (HSPs) from mammals and microbial reagents are among the immunogenic proteins. Their expression is induced in response to a wide variety of physiological and environmental insults. Their functions as molecular chaperones allow cells to adapt to gradual changes in their environment and to survive in otherwise lethal conditions. Although the role of HSPs in atherosclerosis remains controversial, HSPs were thought to act as autoantigens, and trigger both cell- and antibody-mediated immune responses. However, HSPs possess immunoregulatory attributes as well and therefore, are being exploited for immunomodulation of atherosclerosis either by the adaptive or innate immune system. This review will focus on a number of HSPs from different families including HSPE, HSPB, DNAJ, HSPD, HSPA, HSPC and HSPH. The role of these HSPs, their protective vs. immunogenic properties with special emphasis on their potential as targets to develop therapeutic agent against atherosclerosis will be discussed.
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Cite this article as:
Lu X. and Kakkar V., The Role of Heat Shock Protein (HSP) in Atherosclerosis: Pathophysiology and Clinical Opportunities, Current Medicinal Chemistry 2010; 17 (10) . https://dx.doi.org/10.2174/092986710790820688
DOI https://dx.doi.org/10.2174/092986710790820688 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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