Abstract
Body mass index (BMI), serum cytokines and serum obesity markers were evaluated in 33 obese children before, during and after a hypocaloric diet. The cytometric bead array “human inflammatory kit” was used for the evaluation of serum interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor-... On the other hand, the following obesity biomarkers were evaluated by means of a flowcytomixhuman obesity 9 plex kit: Soluble Isoform of CD40 Ligand; Soluble Intercellular Adhesion Molecule-1; Leptin; Monocyte Chemoattractant Protein 1; Myeloperoxidase; Osteoprotegerin; Resistin and Soluble TNF-receptors. Actually, throughout the study modifications of BMI were negligible and, therefore, serum cytokines and obesity markers did not show any significant changes in comparison with baseline values. On the other hand, at the different time points considered the majority of obesity markers were higher than normal controls, thus indicating a low grade inflammation in childhood obesity. Therefore, attempts at reducing this inflammatory status in children which predisposes to the metabolic syndrome outcome are discussed.
Keywords: Body mass index, children, cytokine, inflammation, obesity, serum obesity markers
Current Pharmaceutical Design
Title: Effects of a Hypocaloric Diet on Obesity Biomarkers: Prevention of Low-Grade Inflammation since Childhood
Volume: 16 Issue: 7
Author(s): L. Amati, G. Marzulli, M. Martulli, M. Chiloiro and E. Jirillo
Affiliation:
Keywords: Body mass index, children, cytokine, inflammation, obesity, serum obesity markers
Abstract: Body mass index (BMI), serum cytokines and serum obesity markers were evaluated in 33 obese children before, during and after a hypocaloric diet. The cytometric bead array “human inflammatory kit” was used for the evaluation of serum interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor-... On the other hand, the following obesity biomarkers were evaluated by means of a flowcytomixhuman obesity 9 plex kit: Soluble Isoform of CD40 Ligand; Soluble Intercellular Adhesion Molecule-1; Leptin; Monocyte Chemoattractant Protein 1; Myeloperoxidase; Osteoprotegerin; Resistin and Soluble TNF-receptors. Actually, throughout the study modifications of BMI were negligible and, therefore, serum cytokines and obesity markers did not show any significant changes in comparison with baseline values. On the other hand, at the different time points considered the majority of obesity markers were higher than normal controls, thus indicating a low grade inflammation in childhood obesity. Therefore, attempts at reducing this inflammatory status in children which predisposes to the metabolic syndrome outcome are discussed.
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Cite this article as:
Amati L., Marzulli G., Martulli M., Chiloiro M. and Jirillo E., Effects of a Hypocaloric Diet on Obesity Biomarkers: Prevention of Low-Grade Inflammation since Childhood, Current Pharmaceutical Design 2010; 16 (7) . https://dx.doi.org/10.2174/138161210790883525
DOI https://dx.doi.org/10.2174/138161210790883525 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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