Abstract
Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach and Goldin (LGG®)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbiotic administration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1β and Tumor Necrosis Factor (TNF)-α were lower than normal controls, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly. At T1, the synbiotic was able to significantly increase, depressed values of IL-1β, IL-6 and IL-8 with a trend to a modest increase for the restant cytokines. In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis, even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immune response.
Keywords: Cytokines, immunosenescence, Lactobacillus rhamnosus Gorbach and Goldin (LGG®), oligofructose, probiotics, synbiotics, elderly
Current Pharmaceutical Design
Title: Administration of a Synbiotic to Free-Living Elderly and Evaluation of Serum Cytokines. A Pilot Study
Volume: 16 Issue: 7
Author(s): L. Amati, G. Marzulli, M. Martulli, V. Pugliese, C. Caruso, G. Candore, S. Vasto and E. Jirillo
Affiliation:
Keywords: Cytokines, immunosenescence, Lactobacillus rhamnosus Gorbach and Goldin (LGG®), oligofructose, probiotics, synbiotics, elderly
Abstract: Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach and Goldin (LGG®)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbiotic administration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1β and Tumor Necrosis Factor (TNF)-α were lower than normal controls, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly. At T1, the synbiotic was able to significantly increase, depressed values of IL-1β, IL-6 and IL-8 with a trend to a modest increase for the restant cytokines. In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis, even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immune response.
Export Options
About this article
Cite this article as:
Amati L., Marzulli G., Martulli M., Pugliese V., Caruso C., Candore G., Vasto S. and Jirillo E., Administration of a Synbiotic to Free-Living Elderly and Evaluation of Serum Cytokines. A Pilot Study, Current Pharmaceutical Design 2010; 16 (7) . https://dx.doi.org/10.2174/138161210790883633
DOI https://dx.doi.org/10.2174/138161210790883633 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Identification of Novel 5,6-Dimethoxyindan-1-one Derivatives as Antiviral Agents
Medicinal Chemistry Secondary Prevention of Ischemic Stroke
Current Drug Targets Health Disparities in Women's Health: Current Findings and Future Directions
Current Women`s Health Reviews Role of Class II Nuclear Receptors in Liver Carcinogenesis
Anti-Cancer Agents in Medicinal Chemistry Actionable Nutrigenetics for Genetically Based Diseases? A New Critical Path to P4 Medicine
Current Pharmacogenomics and Personalized Medicine Stressing Conditions as Tools to Boost the Biosynthesis of Valuable Plant Natural Products
Recent Patents on Biotechnology Novel Biomarkers Assessing Endothelial Dysfunction: Role of microRNAs
Current Topics in Medicinal Chemistry Targeting the Human Thioredoxin System by Diverse Strategies to Treat Cancer and Other Pathologies
Recent Patents on DNA & Gene Sequences Animal Models for the Development of New Neuropharmacological Therapeutics in the Status Epilepticus
Current Neuropharmacology Chemokines and Chemokine Receptors Blockers as New Drugs for the Treatment of Chronic Obstructive Pulmonary Disease
Current Medicinal Chemistry Implantable Cardioverter-Defibrillators in Patients with ESRD: Complications, Management, and Literature Review
Current Cardiology Reviews Inhibition of Endotoxin Response by Synthetic TLR4 Antagonists
Current Topics in Medicinal Chemistry Flavonoids in Cancer Prevention
Anti-Cancer Agents in Medicinal Chemistry Potential Application of Induced Pluripotent Stem Cells in Cell Replacement Therapy for Parkinsons Disease
CNS & Neurological Disorders - Drug Targets Low Molecular Weight Compounds with Transition Metals as Free Radical Scavengers and Novel Therapeutic Agents
Cardiovascular & Hematological Agents in Medicinal Chemistry Phytochemicals as Potential Curative Agents against Viral Infection: A Review
Current Organic Chemistry Geriatric Depression - Review for Primary Care
Current Psychiatry Reviews Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants (ASIA) – Animal Models as a Proof of Concept
Current Medicinal Chemistry Alzheimer’s Disease and Molecular Chaperones: Current Knowledge and the Future of Chaperonotherapy
Current Pharmaceutical Design Isoquinolines: Important Cores in Many Marketed and Clinical Drugs
Anti-Cancer Agents in Medicinal Chemistry