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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Cyclic tri- and Pentavalent Amidoesters and Diamides with a Stereogenic Phosphorus Atom in Asymmetric Synthesis: Part I: Stoichiometric Reagents

Author(s): Jozef Drabowicz, Dorota Krasowska, Andrzej Lopusinski, Thomas S.A. Heugebaert and Christian V. Stevens

Volume 14, Issue 5, 2010

Page: [483 - 499] Pages: 17

DOI: 10.2174/138527210790601198

Price: $65

Abstract

This review presents the use of cyclic tri- and pentavalent amidoesters and diamides with a stereogenic phosphorus as chiral stoichiometric auxiliaries in asymmetric synthesis. It shows that these compounds are especially useful for the preparation of selected acyclic enantiomerically (diastereomerically) pure (or enriched) tricoordinated-trivalent and tetracoordinated-pentavalent derivatives and as precursors of stereogenic phosphorus-containing carbanions. Their utility in a few other asymmetric reactions is also discussed.


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