Abstract
DNA exhibits many attractive features in the development of drug design and disease treatment, and there are some successful events for drugs targeting to DNA in clinic use. Nowadays, the specific recognition of DNA by small molecules is the crucial factor of the sustainable development of DNA-target drugs, for the serious side-effects of existing drugs. In this review, we discussed the current efforts of DNA-drug specific interaction that concerned with various DNA recognition models, such as abasic, mismatch or bulge site recognition, specific sequence recognition, and secondary structure recognition. Some compounds are found to show remarkable potential to be ideal drug.
Keywords: DNA specific recognition, small molecules, interaction
Current Medicinal Chemistry
Title: Specific Recognition of DNA by Small Molecules
Volume: 17 Issue: 2
Author(s): Y. H. Du, J. Huang, X. C. Weng and X. Zhou
Affiliation:
Keywords: DNA specific recognition, small molecules, interaction
Abstract: DNA exhibits many attractive features in the development of drug design and disease treatment, and there are some successful events for drugs targeting to DNA in clinic use. Nowadays, the specific recognition of DNA by small molecules is the crucial factor of the sustainable development of DNA-target drugs, for the serious side-effects of existing drugs. In this review, we discussed the current efforts of DNA-drug specific interaction that concerned with various DNA recognition models, such as abasic, mismatch or bulge site recognition, specific sequence recognition, and secondary structure recognition. Some compounds are found to show remarkable potential to be ideal drug.
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Cite this article as:
Du H. Y., Huang J., Weng C. X. and Zhou X., Specific Recognition of DNA by Small Molecules, Current Medicinal Chemistry 2010; 17 (2) . https://dx.doi.org/10.2174/092986710790112648
DOI https://dx.doi.org/10.2174/092986710790112648 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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