Abstract
Several observational and experimental studies show the beneficial effects of ω-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of ω-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of ω-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and antiinflammatory mechanisms underlying their clinical benefits.
Keywords: Polyunsaturated fatty acids, cardiovascular disease, sudden death, coronary heart disease, heart failure
Current Pharmaceutical Design
Title: Polyunsaturated Fatty Acids and Cardiovascular Disease
Volume: 15 Issue: 36
Author(s): Ivan Calzolari, Stefano Fumagalli, Niccolo Marchionni and Mauro Di Bari
Affiliation:
Keywords: Polyunsaturated fatty acids, cardiovascular disease, sudden death, coronary heart disease, heart failure
Abstract: Several observational and experimental studies show the beneficial effects of ω-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of ω-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of ω-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and antiinflammatory mechanisms underlying their clinical benefits.
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Cite this article as:
Calzolari Ivan, Fumagalli Stefano, Marchionni Niccolo and Di Bari Mauro, Polyunsaturated Fatty Acids and Cardiovascular Disease, Current Pharmaceutical Design 2009; 15 (36) . https://dx.doi.org/10.2174/138161209789909755
DOI https://dx.doi.org/10.2174/138161209789909755 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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