Abstract
All forms of diabetes are increasing in prevalence, but with the advent of the obesity epidemic, we now face the prospect of an increasing number of women conceiving whilst taking traditional oral antidiabetic agents (OADs). This is also further complicated by the availability of new incretin-based therapies, the dipeptidylpeptidase-4 (DPP-IV) inhibitors and glucagon-like-1 receptor (GLP-1R) analogues. Original concerns regarding the use of such OADs have meant that diet control and insulin has been the mainstay of treatment for hyperglycaemia during pregnancy. However, recent NICE guidelines have suggested a role for oral antidiabetic agents. Safety is of paramount concern, especially in pregnancy, and this review will discuss the evidence to date.
Keywords: OADs, Metformin, Sulphonylureas, TZDS, DPP-IV inhibitors, GLP-1 analogues, Pregnancy
Current Diabetes Reviews
Title: Diabetic Medications in Pregnancy
Volume: 5 Issue: 4
Author(s): James Young and Aresh Anwar
Affiliation:
Keywords: OADs, Metformin, Sulphonylureas, TZDS, DPP-IV inhibitors, GLP-1 analogues, Pregnancy
Abstract: All forms of diabetes are increasing in prevalence, but with the advent of the obesity epidemic, we now face the prospect of an increasing number of women conceiving whilst taking traditional oral antidiabetic agents (OADs). This is also further complicated by the availability of new incretin-based therapies, the dipeptidylpeptidase-4 (DPP-IV) inhibitors and glucagon-like-1 receptor (GLP-1R) analogues. Original concerns regarding the use of such OADs have meant that diet control and insulin has been the mainstay of treatment for hyperglycaemia during pregnancy. However, recent NICE guidelines have suggested a role for oral antidiabetic agents. Safety is of paramount concern, especially in pregnancy, and this review will discuss the evidence to date.
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Cite this article as:
Young James and Anwar Aresh, Diabetic Medications in Pregnancy, Current Diabetes Reviews 2009; 5 (4) . https://dx.doi.org/10.2174/157339909789804350
DOI https://dx.doi.org/10.2174/157339909789804350 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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