Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

Title: Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

Volume: 9 Issue: 5

Author(s): Juan F. Vera, Malcolm K. Brenner and Gianpietro Dotti

Affiliation:

Abstract: Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

Cite this article as:

Vera F. Juan, Brenner K. Malcolm and Dotti Gianpietro, Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes, Current Gene Therapy 2009; 9 (5) . https://dx.doi.org/10.2174/156652309789753338