Abstract
High Content Screening (HCS) and High Content Analysis (HCA) have emerged over the past 10 years as a powerful technology for both drug discovery and systems biology. Founded on the automated, quantitative image analysis of fluorescently labeled cells or engineered cell lines, HCS provides unparalleled levels of multi-parameter data on cellular events and is being widely adopted, with great benefits, in many aspects of life science from gaining a better understanding of disease processes, through better models of toxicity, to generating systems views of cellular processes. This paper looks at the role of informatics and bioinformatics in both enabling and driving HCS to further our understanding of both the genome and the cellome and looks into the future to see where such deep knowledge could take us.
Keywords: High content screening, HCS, high content analysis, HCA, genomics, informatics, bioinformatics, ontology, systems biology, drug discovery
Combinatorial Chemistry & High Throughput Screening
Title: Generating ‘Omic Knowledge’: The Role of Informatics in High Content Screening
Volume: 12 Issue: 9
Author(s): Mark A. Collins*
Affiliation:
- Cellular Imaging&Analysis, Thermo Fisher Scientific, 100 Technology Drive, Pittsburgh PA 15219, USA.,United States
Keywords: High content screening, HCS, high content analysis, HCA, genomics, informatics, bioinformatics, ontology, systems biology, drug discovery
Abstract: High Content Screening (HCS) and High Content Analysis (HCA) have emerged over the past 10 years as a powerful technology for both drug discovery and systems biology. Founded on the automated, quantitative image analysis of fluorescently labeled cells or engineered cell lines, HCS provides unparalleled levels of multi-parameter data on cellular events and is being widely adopted, with great benefits, in many aspects of life science from gaining a better understanding of disease processes, through better models of toxicity, to generating systems views of cellular processes. This paper looks at the role of informatics and bioinformatics in both enabling and driving HCS to further our understanding of both the genome and the cellome and looks into the future to see where such deep knowledge could take us.
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Cite this article as:
Collins A. Mark*, Generating ‘Omic Knowledge’: The Role of Informatics in High Content Screening, Combinatorial Chemistry & High Throughput Screening 2009; 12 (9) . https://dx.doi.org/10.2174/138620709789383259
DOI https://dx.doi.org/10.2174/138620709789383259 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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