Abstract
Mycophenolic acid (MPA) is a basis for the immunosuppressive drugs used in clinic against rejection in solid organs transplantations. Since its physiological activity is very promising, numerous studies have been performed to establish mechanism of action, structure — activity relationship (SAR), synthesis of MPA derivatives to improve or extent its clinical use to anticancer one, especially. The reported methods for preparation of MPA analogues have been achieved by semi-synthetic approaches or total synthesis and accomplished by in vitro or / and in vivo evaluations. In this review we would like to bring together chemical aspects of these compounds and their implementations within biological activity, their synthesis and structural modifications referred to the structure-activity relationship (SAR).
Keywords: Mycophenolic acid, MPA, MPA analogues
Current Medicinal Chemistry
Title: The Chemistry of Mycophenolic Acid - Synthesis and Modifications Towards Desired Biological Activity
Volume: 17 Issue: 18
Author(s): G. Cholewinski, M. Malachowska-Ugarte and K. Dzierzbicka
Affiliation:
Keywords: Mycophenolic acid, MPA, MPA analogues
Abstract: Mycophenolic acid (MPA) is a basis for the immunosuppressive drugs used in clinic against rejection in solid organs transplantations. Since its physiological activity is very promising, numerous studies have been performed to establish mechanism of action, structure — activity relationship (SAR), synthesis of MPA derivatives to improve or extent its clinical use to anticancer one, especially. The reported methods for preparation of MPA analogues have been achieved by semi-synthetic approaches or total synthesis and accomplished by in vitro or / and in vivo evaluations. In this review we would like to bring together chemical aspects of these compounds and their implementations within biological activity, their synthesis and structural modifications referred to the structure-activity relationship (SAR).
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Cite this article as:
Cholewinski G., Malachowska-Ugarte M. and Dzierzbicka K., The Chemistry of Mycophenolic Acid - Synthesis and Modifications Towards Desired Biological Activity, Current Medicinal Chemistry 2010; 17 (18) . https://dx.doi.org/10.2174/092986710791163920
DOI https://dx.doi.org/10.2174/092986710791163920 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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