Abstract
The objective of the study was to evaluate the efficacy of insulin loaded polymerosomes in diabetic rat model. To achieve the purpose, amphiphilic triblock co-polymers of the class poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone), CEC were synthesized by ring-opening polymerization and characterized. Polymerosomes were prepared by double emulsion method in the size range of 75-130 nm at 25 °C as measured by differential light scattering technique. Insulin was loaded in situ during nanoparticle preparation. The release of insulin was observed to be critically dependent on the caprolactone/ethylene glycol ratio and particle size. The pharmacological activity ranged from 22-36 h for various polymerosomes formulations in comparison to poly(caprolactone), PCL nanoparticles which reached the basal level after 4 h of administration. The polymerosomes were therefore seen to enhance the insulin activity as well as its stability in physiological fluid for a prolonged duration.
Keywords: Polymerosomes, poly(caprolactone), poly(ethylene glycol), insulin, release behaviour, in vivo evaluation
Current Nanoscience
Title: Polymerosomes of PCL and PEG Demonstrate Enhanced Therapeutic Efficacy of Insulin
Volume: 5 Issue: 4
Author(s): Rachna Rastogi, Sneh Anand and Veena Koul
Affiliation:
Keywords: Polymerosomes, poly(caprolactone), poly(ethylene glycol), insulin, release behaviour, in vivo evaluation
Abstract: The objective of the study was to evaluate the efficacy of insulin loaded polymerosomes in diabetic rat model. To achieve the purpose, amphiphilic triblock co-polymers of the class poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone), CEC were synthesized by ring-opening polymerization and characterized. Polymerosomes were prepared by double emulsion method in the size range of 75-130 nm at 25 °C as measured by differential light scattering technique. Insulin was loaded in situ during nanoparticle preparation. The release of insulin was observed to be critically dependent on the caprolactone/ethylene glycol ratio and particle size. The pharmacological activity ranged from 22-36 h for various polymerosomes formulations in comparison to poly(caprolactone), PCL nanoparticles which reached the basal level after 4 h of administration. The polymerosomes were therefore seen to enhance the insulin activity as well as its stability in physiological fluid for a prolonged duration.
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Cite this article as:
Rastogi Rachna, Anand Sneh and Koul Veena, Polymerosomes of PCL and PEG Demonstrate Enhanced Therapeutic Efficacy of Insulin, Current Nanoscience 2009; 5 (4) . https://dx.doi.org/10.2174/157341309789378078
DOI https://dx.doi.org/10.2174/157341309789378078 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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