Abstract
Despite substantial therapeutic advances, heart failure remains a syndrome associated with high morbidity and mortality. The management of heart failure remains challenging despite the recent different therapeutic advances. The emergence of cardiac biomarkers as increasingly effective clinical tools suggests the potential of a new approach to the management of patients with heart failure. A variety of circulating biomarkers of diagnostic and prognostic utility in heart failure is currently being studied in preclinical, observational and randomized prospective studies. Of the various candidate biomarkers, the greatest wealth of knowledge and clinical experience lies with the B-type naturetic peptides. However, because individual biomarkers may have limited sensitivity and specificity, a multi-marker approach, using combinations of different biomarkers that reflect different aspects of the pathophysiological milieu, would contribute to better risk stratification and optimization of therapy.
Keywords: Biomarkers, heart failure, diagnosis, prognosis
Current Medicinal Chemistry
Title: Circulating Biomarkers for the Diagnosis and Prognosis of Heart Failure
Volume: 16 Issue: 29
Author(s): D. Tousoulis, A. Kampoli, G. Siasos, E. Stefanadi, C. Antoniades, A. G. Papavassiliou and C. Stefanadis
Affiliation:
Keywords: Biomarkers, heart failure, diagnosis, prognosis
Abstract: Despite substantial therapeutic advances, heart failure remains a syndrome associated with high morbidity and mortality. The management of heart failure remains challenging despite the recent different therapeutic advances. The emergence of cardiac biomarkers as increasingly effective clinical tools suggests the potential of a new approach to the management of patients with heart failure. A variety of circulating biomarkers of diagnostic and prognostic utility in heart failure is currently being studied in preclinical, observational and randomized prospective studies. Of the various candidate biomarkers, the greatest wealth of knowledge and clinical experience lies with the B-type naturetic peptides. However, because individual biomarkers may have limited sensitivity and specificity, a multi-marker approach, using combinations of different biomarkers that reflect different aspects of the pathophysiological milieu, would contribute to better risk stratification and optimization of therapy.
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Cite this article as:
Tousoulis D., Kampoli A., Siasos G., Stefanadi E., Antoniades C., Papavassiliou G. A. and Stefanadis C., Circulating Biomarkers for the Diagnosis and Prognosis of Heart Failure, Current Medicinal Chemistry 2009; 16 (29) . https://dx.doi.org/10.2174/092986709789178000
DOI https://dx.doi.org/10.2174/092986709789178000 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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