Abstract
This review deals with the asymmetric alkynylation of imines (and iminium ions) to give chiral nonracemic propargylamines. Diastereoselective procedures involved the addition of metal alkynylides to chiral nonracemic imines derived from chiral amines or chiral carbonyl compounds. Enantioselective non-catalytic procedures have been achieved with the use of stoichiometric additives or alkynylboron reagents. Finally, catalytic addition of terminal alkynes or zinc acetylides has been carried out in the presence of chiral metal complexes, especially copper complexes as catalysts.
Current Organic Chemistry
Title: Recent Developments in Asymmetric Alkynylation of Imines
Volume: 13 Issue: 15
Author(s): G. Blay, A. Monleon and J. R. Pedro
Affiliation:
Abstract: This review deals with the asymmetric alkynylation of imines (and iminium ions) to give chiral nonracemic propargylamines. Diastereoselective procedures involved the addition of metal alkynylides to chiral nonracemic imines derived from chiral amines or chiral carbonyl compounds. Enantioselective non-catalytic procedures have been achieved with the use of stoichiometric additives or alkynylboron reagents. Finally, catalytic addition of terminal alkynes or zinc acetylides has been carried out in the presence of chiral metal complexes, especially copper complexes as catalysts.
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Cite this article as:
Blay G., Monleon A. and Pedro R. J., Recent Developments in Asymmetric Alkynylation of Imines, Current Organic Chemistry 2009; 13 (15) . https://dx.doi.org/10.2174/138527209789177734
DOI https://dx.doi.org/10.2174/138527209789177734 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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