Abstract
Statins are widely prescribed cholesterol lowering agents that exert their effects by inhibiting 3-hydroxy- 3methylglutaryl co-enzyme A reductase. With their modulatory effects on the atherogenic lipid profile, the role of statin therapy is expanding amidst the growing obesity epidemic. The cholesterol lowering effects of statin therapy remain central in the long term management of coronary artery disease and cerebrovascular disease. While statin therapy is used commonly to target elevated LDL cholesterol, there is an emerging evidence supporting its role during acute coronary syndromes and stroke. Clinical research into plaque histology, vulnerable high risk plaques and plaque rupture has improved our insight into the pathophysiology of these acute vascular events. Non lipid lowering effects of statin, the so called pleitrophic effects, have become the focal point of investigation. This review discusses recent experimental and clinical evidence supporting the role of statin in perioperative medicine.
Keywords: HMG CoA reductase inhibitors, pleiotropic effects, isoprenoids, atherogenesis, inflammation, perioperative metabolism, surgery, vulnerable plaque
Current Drug Targets
Title: Role of Statins in Peri-Operative Medicine
Volume: 10 Issue: 9
Author(s): H. S. Bagry and F. Carli
Affiliation:
Keywords: HMG CoA reductase inhibitors, pleiotropic effects, isoprenoids, atherogenesis, inflammation, perioperative metabolism, surgery, vulnerable plaque
Abstract: Statins are widely prescribed cholesterol lowering agents that exert their effects by inhibiting 3-hydroxy- 3methylglutaryl co-enzyme A reductase. With their modulatory effects on the atherogenic lipid profile, the role of statin therapy is expanding amidst the growing obesity epidemic. The cholesterol lowering effects of statin therapy remain central in the long term management of coronary artery disease and cerebrovascular disease. While statin therapy is used commonly to target elevated LDL cholesterol, there is an emerging evidence supporting its role during acute coronary syndromes and stroke. Clinical research into plaque histology, vulnerable high risk plaques and plaque rupture has improved our insight into the pathophysiology of these acute vascular events. Non lipid lowering effects of statin, the so called pleitrophic effects, have become the focal point of investigation. This review discusses recent experimental and clinical evidence supporting the role of statin in perioperative medicine.
Export Options
About this article
Cite this article as:
Bagry S. H. and Carli F., Role of Statins in Peri-Operative Medicine, Current Drug Targets 2009; 10 (9) . https://dx.doi.org/10.2174/138945009789108783
DOI https://dx.doi.org/10.2174/138945009789108783 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Melatonin in Cardiac Ischemia/Reperfusion-Induced Mitochondrial Adaptive Changes
Cardiovascular & Hematological Disorders-Drug Targets Lifestyle Factors and Endothelial Function
Current Vascular Pharmacology The Chaperone-like Activity of Rat HspB8/Hsp22 and Dynamic Molecular Transition Related to Oligomeric Architectures In Vitro
Protein & Peptide Letters Comparative Efficacy and Safety of Duration of Dual Antiplatelet Therapy in Patients with CAD Undergoing Drug-eluting Stent Implantation: A Systematic Review and Network Meta-analysis
Current Pharmaceutical Design Regulation of Angiogenesis and Angiogenic Factors by Cardiovascular Medications
Current Pharmaceutical Design Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death
Current Neurovascular Research Diagnosis and Management of Chronic Coronary Artery Disease
Current Cardiology Reviews Heat Shock Proteins Protect Against Ischemia and Inflammation Through Multiple Mechanisms
Inflammation & Allergy - Drug Targets (Discontinued) Prognostic Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy, Major Adverse Cardiac Events, and Mortality in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention
Current Cardiology Reviews Iron Oxide Nanoparticles: An Insight into their Biomedical Applications
Current Medicinal Chemistry Selenoproteins and their Role in Oxidative Stress and Inflammation
Current Chemical Biology Pleiotropic Effects of Drugs Inhibiting the Renin-Angiotensin-Aldosterone System
Current Pharmaceutical Design Non-Viral Gene Delivery Methods
Current Pharmaceutical Biotechnology Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance
Current Neuropharmacology Current Evidence for Antithrombotic Therapy after Peripheral Vascular Interventions
Current Vascular Pharmacology Adipose Tissue and Bone Marrow as Sources for Cell-based Therapeutic Angiogenesis in Ischemic Tissues: Biological Foundation and Clinical Prospects for Age-related Vascular Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Possible Therapeutic Targets in Cardiac Myocyte Apoptosis
Current Pharmaceutical Design Impaired Expression and Function of Cancer-Related Enzymes by Anthocyans: An Update
Current Enzyme Inhibition ATP-Containing Immunoliposomes Specific for Cardiac Myosin
Current Drug Delivery Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience
Current Drug Targets