Abstract
Reactive oxygen species (ROS), as well as reactive nitrogen species (RNS) play either harmful or beneficial role in biological systems. Beneficial effects of ROS include physiological roles in cellular responses against infectious agents and in several cellular signalling pathways. Harmful effects are due to high concentrations of ROS, which can damage biomolecules, including lipids, proteins and nucleic acids. The harmful effects of ROS are counterbalanced by the antioxidant action of both antioxidant enzymes and non-enzymatic antioxidants; however, despite the presence of the cells antioxidant system, oxidative damage accumulates during the life cycle and has been proposed to play a pivotal role in the development of age-dependent diseases such as atherosclerosis, arthritis, neurodegenerative disorders and cancer. Numerous epidemiological studies indicate that a reduced risk of various lifestyle diseases, mainly cardiovascular diseases and cancer, as well as other disorders, is associated to a diet rich in fruits, vegetables and their products. The drive to enhance the consumption of fruits and vegetables in the human diet is linked with positive effects of beneficial antioxidants impacting on health promotion. In this review we present an outline of main roles of ROS in biological processes and diseases and how natural bioactive compounds of fruits and vegetables determine their health-promoting properties.
Keywords: Antioxidants, oxidative stress, reactive oxygen species
Current Pharmaceutical Design
Title: Antioxidant Effects of Natural Bioactive Compounds
Volume: 15 Issue: 26
Author(s): Clara Balsano and Anna Alisi
Affiliation:
Keywords: Antioxidants, oxidative stress, reactive oxygen species
Abstract: Reactive oxygen species (ROS), as well as reactive nitrogen species (RNS) play either harmful or beneficial role in biological systems. Beneficial effects of ROS include physiological roles in cellular responses against infectious agents and in several cellular signalling pathways. Harmful effects are due to high concentrations of ROS, which can damage biomolecules, including lipids, proteins and nucleic acids. The harmful effects of ROS are counterbalanced by the antioxidant action of both antioxidant enzymes and non-enzymatic antioxidants; however, despite the presence of the cells antioxidant system, oxidative damage accumulates during the life cycle and has been proposed to play a pivotal role in the development of age-dependent diseases such as atherosclerosis, arthritis, neurodegenerative disorders and cancer. Numerous epidemiological studies indicate that a reduced risk of various lifestyle diseases, mainly cardiovascular diseases and cancer, as well as other disorders, is associated to a diet rich in fruits, vegetables and their products. The drive to enhance the consumption of fruits and vegetables in the human diet is linked with positive effects of beneficial antioxidants impacting on health promotion. In this review we present an outline of main roles of ROS in biological processes and diseases and how natural bioactive compounds of fruits and vegetables determine their health-promoting properties.
Export Options
About this article
Cite this article as:
Balsano Clara and Alisi Anna, Antioxidant Effects of Natural Bioactive Compounds, Current Pharmaceutical Design 2009; 15 (26) . https://dx.doi.org/10.2174/138161209789058084
DOI https://dx.doi.org/10.2174/138161209789058084 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Linking New Paradigms in Protein Chemistry to Reversible Membrane-Protein Interactions
Current Protein & Peptide Science Cardiac ATP-Sensitive Potassium Channels: A Potential Target for an Anti-Ischaemic Pharmacological Strategy
Cardiovascular & Hematological Agents in Medicinal Chemistry Recent Progress in Gene Therapy for Parkinson’s Disease
Current Molecular Medicine The Protective Effects of Jatrorrhizine on β-Amyloid (25-35)-Induced Neurotoxicity in Rat Cortical Neurons
CNS & Neurological Disorders - Drug Targets Pathophysiology of Transmissible Spongiform Encephalopathies
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents New Insights into Biological Markers of Frontotemporal Lobar Degeneration Spectrum
Current Medicinal Chemistry Potential Roles of Selenium and Selenoproteins in the Prevention of Alzheimer's Disease
Current Topics in Medicinal Chemistry Heme Oxygenase-2 Protects Against Glutathione Depletion-induced Neuronal Apoptosis Mediated by Bilirubin and Cyclic GMP
Current Neurovascular Research Use of the Adamantane Structure in Medicinal Chemistry
Current Medicinal Chemistry Decline of Executive Processes Affects the Identification of Emotional Facial Expressions in Aging
Current Aging Science Deciphering the Role of Aberrant Protein Post-Translational Modification in the Pathology of Neurodegeneration
CNS & Neurological Disorders - Drug Targets Perspectives on Medicinal Properties of Mangiferin
Mini-Reviews in Medicinal Chemistry Meet Our Editorial Board Member
Current Neuropharmacology Is there a Rational Approach for Increasing Drug Specificity? Considerations on CNS Target Choice and Validation
Recent Patents on CNS Drug Discovery (Discontinued) Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer’s Disease
Current Medicinal Chemistry Editorial (Thematic Issue: Immunotherapy in Central Nervous System)
Current Pharmaceutical Biotechnology Contemporary Anticholinesterase Pharmaceuticals of Natural Origin and Their Synthetic Analogues for the Treatment of Alzheimers Disease
Recent Patents on CNS Drug Discovery (Discontinued) Nanotechnology: A Novel Approach for Drug Development in Health Care System
Current Nanomaterials Population-based Study of Risk Polymorphisms Associated with Vascular Disorders and Dementia
Current Genomics Peptides and their Metal Complexes in Neurodegenerative Diseases: from Structural Studies to Nanomedicine Prospects
Current Medicinal Chemistry