Abstract
Casein Kinase I η (CKI) and Casein Kinase I δ (CKIδ) are Serine/Threonine Kinases that have been implicated in several human conditions and have been receiving increasing attention as potential therapeutic targets. Recent findings in gastrointestinal cancers strengthen this notion and suggest that they may also play important roles in both colon cancer and pancreatic cancer, which are among the most common and deadly cancers affecting both men and women. In this short review, we summarize up to date what is known about these two kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in gastrointestinal cancers and their potential for screening and cancer therapy.
Keywords: CKIη, CKIδ, colon cancer, pancreatic cancer, biomarkers, IC261
Current Cancer Therapy Reviews
Title: Roles of Casein Kinase I η and δ in Gastrointestinal Cancers: Potential New Screening Markers and Drug Targets
Volume: 5 Issue: 3
Author(s): Cristina Modak and Jianyuan Chai
Affiliation:
Keywords: CKIη, CKIδ, colon cancer, pancreatic cancer, biomarkers, IC261
Abstract: Casein Kinase I η (CKI) and Casein Kinase I δ (CKIδ) are Serine/Threonine Kinases that have been implicated in several human conditions and have been receiving increasing attention as potential therapeutic targets. Recent findings in gastrointestinal cancers strengthen this notion and suggest that they may also play important roles in both colon cancer and pancreatic cancer, which are among the most common and deadly cancers affecting both men and women. In this short review, we summarize up to date what is known about these two kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in gastrointestinal cancers and their potential for screening and cancer therapy.
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Modak Cristina and Chai Jianyuan, Roles of Casein Kinase I η and δ in Gastrointestinal Cancers: Potential New Screening Markers and Drug Targets, Current Cancer Therapy Reviews 2009; 5 (3) . https://dx.doi.org/10.2174/157339409788982214
DOI https://dx.doi.org/10.2174/157339409788982214 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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