Abstract
Casein Kinase I η (CKI) and Casein Kinase I δ (CKIδ) are Serine/Threonine Kinases that have been implicated in several human conditions and have been receiving increasing attention as potential therapeutic targets. Recent findings in gastrointestinal cancers strengthen this notion and suggest that they may also play important roles in both colon cancer and pancreatic cancer, which are among the most common and deadly cancers affecting both men and women. In this short review, we summarize up to date what is known about these two kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in gastrointestinal cancers and their potential for screening and cancer therapy.
Keywords: CKIη, CKIδ, colon cancer, pancreatic cancer, biomarkers, IC261
Current Cancer Therapy Reviews
Title: Roles of Casein Kinase I η and δ in Gastrointestinal Cancers: Potential New Screening Markers and Drug Targets
Volume: 5 Issue: 3
Author(s): Cristina Modak and Jianyuan Chai
Affiliation:
Keywords: CKIη, CKIδ, colon cancer, pancreatic cancer, biomarkers, IC261
Abstract: Casein Kinase I η (CKI) and Casein Kinase I δ (CKIδ) are Serine/Threonine Kinases that have been implicated in several human conditions and have been receiving increasing attention as potential therapeutic targets. Recent findings in gastrointestinal cancers strengthen this notion and suggest that they may also play important roles in both colon cancer and pancreatic cancer, which are among the most common and deadly cancers affecting both men and women. In this short review, we summarize up to date what is known about these two kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in gastrointestinal cancers and their potential for screening and cancer therapy.
Export Options
About this article
Cite this article as:
Modak Cristina and Chai Jianyuan, Roles of Casein Kinase I η and δ in Gastrointestinal Cancers: Potential New Screening Markers and Drug Targets, Current Cancer Therapy Reviews 2009; 5 (3) . https://dx.doi.org/10.2174/157339409788982214
DOI https://dx.doi.org/10.2174/157339409788982214 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genomic and Epigenomic Instability, Fragile Sites, Schizophrenia and Autism
Current Genomics Bioinorganic Chemistry: The Study of the Fate of Platinum-Based Antitumour Drugs
Current Chemical Biology Recent Developments in Delivery of Nucleic Acid-Based Antiviral Agents
Current Pharmaceutical Design Emerging Potential of Natural Products as an Alternative Strategy to Pharmacological Agents Used Against Metabolic Disorders
Current Drug Metabolism Therapeutic Potential of Natural Compounds that Regulate the Activity of Protein Kinase C
Current Medicinal Chemistry Choline Kinase Alpha Depletion Selectively Kills Tumoral Cells
Current Cancer Drug Targets Induction of Apoptosis by Curcumin and Its Implications for Cancer Therapy
Current Cancer Drug Targets Circulating Biomarkers for Tumor Angiogenesis: Where Are We?
Current Medicinal Chemistry Preformulation Designed to Enable Discovery and Assess Developability
Combinatorial Chemistry & High Throughput Screening Relative In Vitro Potentials of Parthenolide to Induce Apoptosis and Cell Cycle Arrest in Skin Cancer Cells
Current Drug Discovery Technologies Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection
Current Drug Metabolism Microparticles: A Pivotal Nexus in Vascular Homeostasis and Disease
Current Clinical Pharmacology Design, Synthesis and Biological Evaluation of a Novel Series of Indole-3- Carboxamide Derivatives for Cancer Treatment as EGFR Inhibitors
Letters in Drug Design & Discovery New Advances in the Pathogenesis and Progression of Barrett’s Esophagus
Current Molecular Medicine Current Role of Proteomics in Pancreatic Cancer Biomarkers Research
Current Proteomics Subject Index To Volume 7
Current Pharmaceutical Design Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges
Current Vascular Pharmacology Perfusion Computed Tomography and its Application in Oncologic Practice
Current Molecular Imaging (Discontinued) Investigating Drug Repositioning Approach to Design Novel Prodrugs for Colon-specific Release of Fexofenadine for Ulcerative Colitis
Current Drug Delivery Pore-forming Peptides: A New Treatment Option for Cancer
Current Medicinal Chemistry