Abstract
Sepsis is a major disease entity with important clinical implications. It is associated with a high mortality rate in humans. Recently, several studies have demonstrated that Intensive Care Unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration and/or global loss of cognitive function. The pathogenesis of septic encephalopathy and cognitive impairment are still poorly known and further understanding of these processes is necessary for the development of effective preventive and therapeutic interventions. Here we discuss the clinical presentation and underlying pathophysiology of the encephalopathy and neurobiology of the cognitive impairment associated with sepsis.
Keywords: Cognitive impairment, memory, encephalopathy, sepsis
Current Neurovascular Research
Title: Cognitive Impairment in the Septic Brain
Volume: 6 Issue: 3
Author(s): Clarissa M. Comim, Leandra C. Constantino, Tatiana Barichello, Emilio L. Streck, Joao Quevedo and Felipe Dal-Pizzol
Affiliation:
Keywords: Cognitive impairment, memory, encephalopathy, sepsis
Abstract: Sepsis is a major disease entity with important clinical implications. It is associated with a high mortality rate in humans. Recently, several studies have demonstrated that Intensive Care Unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration and/or global loss of cognitive function. The pathogenesis of septic encephalopathy and cognitive impairment are still poorly known and further understanding of these processes is necessary for the development of effective preventive and therapeutic interventions. Here we discuss the clinical presentation and underlying pathophysiology of the encephalopathy and neurobiology of the cognitive impairment associated with sepsis.
Export Options
About this article
Cite this article as:
Comim M. Clarissa, Constantino C. Leandra, Barichello Tatiana, Streck L. Emilio, Quevedo Joao and Dal-Pizzol Felipe, Cognitive Impairment in the Septic Brain, Current Neurovascular Research 2009; 6 (3) . https://dx.doi.org/10.2174/156720209788970045
DOI https://dx.doi.org/10.2174/156720209788970045 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Improving Adherence to Antipsychotic Pharmacotherapy
Current Clinical Pharmacology NO News is not Necessarily Good News in Cancer
Current Cancer Drug Targets Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands
Letters in Organic Chemistry The Effects of Sevoflurane or Remifentanil on the Stress Response to Surgical Stimulus
Current Pharmaceutical Design Integrating Pharmacogenetics for Assessment of Herb-Drug Interactions: Has the Time Come?
Current Pharmacogenomics and Personalized Medicine Beneficial Effects of Corn Silk on Metabolic Syndrome
Current Pharmaceutical Design Rationalizing the Study of Plants for the Treatment of Oral Pain
Current Chemical Biology Relative Survival Benefit and Morbidity with Fluids in Severe Sepsis - A Network Meta-Analysis of Alternative Therapies
Current Drug Safety Editorial [Hot Topic: Autoimmunity (Executive Editors: D. Stahl and W. Sibrowski)]
Current Pharmaceutical Design Current Treatment of Autoimmune Blistering Diseases
Current Drug Discovery Technologies Brain Perfusion In Sepsis
Current Vascular Pharmacology Near Infrared Spectroscopy in Healthy Preterm and Term Newborns: Correlation with Gestational Age and Standard Monitoring Parameters
Current Neurovascular Research Toxicological Effects of Dietary Biogenic Amines
Current Nutrition & Food Science The Potential of Tetrandrine Against Gliomas
Anti-Cancer Agents in Medicinal Chemistry Neuroprotective Role of Hypothermia in Hypoxic-ischemic Brain Injury: Combined Therapies using Estrogen
Current Neuropharmacology Hypersensitivity to Antineoplastic Agents
Current Pharmaceutical Design Endocannabinoids and their Involvement in the Neurovascular System
Current Neurovascular Research Cyclodextrin Based Nanosponges: A Multidimensional Drug Delivery System and its Biomedical Applications
Current Drug Delivery Genetically Engineered Elastin-based Biomaterials for Biomedical Applications
Current Medicinal Chemistry Vascular Endothelin and Hypertension - From Receptors to Medicine
Current Hypertension Reviews