Abstract
A decrease in the number of functioning pancreatic β-cells and insufficient insulin biosynthesis and/or secretion are the hallmarks of diabetes. Therefore, the identification of alternative sources to induce insulin-producing surrogate β-cells is of great importance. For the induction of insulin-producing cells from various cells and/or tissues, it is useful to mimic and reproduce expression alterations of various pancreatic transcription factors observed during normal pancreas development and to induce key pancreatic transcription factors which have the potency to induce insulin and other β-cell-related genes. MafA, PDX-1 and NeuroD directly bind to the insulin gene promoter and function as very important transcription factors in pancreatic β-cell differentiation and mature β-cell function. The combination of MafA, PDX-1 and NeuroD markedly induces insulin biosynthesis in various non-β-cells and thereby is a useful tool to efficiently induce insulin- producing surrogate β-cells.
Keywords: MafA, PDX-1, NeuroD, β-cell differentiation, surrogate β-cells
Current Medicinal Chemistry
Title: Combination of MafA, PDX-1 and NeuroD is a Useful Tool to Efficiently Induce Insulin-Producing Surrogate β -Cells
Volume: 16 Issue: 24
Author(s): Hideaki Kaneto, Taka-aki Matsuoka, Naoto Katakami and Munehide Matsuhisa
Affiliation:
Keywords: MafA, PDX-1, NeuroD, β-cell differentiation, surrogate β-cells
Abstract: A decrease in the number of functioning pancreatic β-cells and insufficient insulin biosynthesis and/or secretion are the hallmarks of diabetes. Therefore, the identification of alternative sources to induce insulin-producing surrogate β-cells is of great importance. For the induction of insulin-producing cells from various cells and/or tissues, it is useful to mimic and reproduce expression alterations of various pancreatic transcription factors observed during normal pancreas development and to induce key pancreatic transcription factors which have the potency to induce insulin and other β-cell-related genes. MafA, PDX-1 and NeuroD directly bind to the insulin gene promoter and function as very important transcription factors in pancreatic β-cell differentiation and mature β-cell function. The combination of MafA, PDX-1 and NeuroD markedly induces insulin biosynthesis in various non-β-cells and thereby is a useful tool to efficiently induce insulin- producing surrogate β-cells.
Export Options
About this article
Cite this article as:
Kaneto Hideaki, Matsuoka Taka-aki, Katakami Naoto and Matsuhisa Munehide, Combination of MafA, PDX-1 and NeuroD is a Useful Tool to Efficiently Induce Insulin-Producing Surrogate β -Cells, Current Medicinal Chemistry 2009; 16 (24) . https://dx.doi.org/10.2174/092986709788802980
DOI https://dx.doi.org/10.2174/092986709788802980 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Therapeutic Proteins for Treatment of Corneal Epithelial Defects
Current Medicinal Chemistry Physicians’ Perception About Use of Vitamin B12 in the Treatment or Prevention of Diabetic Neuropathy: A Cross-sectional Survey in Saudi Arabia
Current Diabetes Reviews Cardiovascular Complications of HIV Infection and Treatment
Cardiovascular & Hematological Agents in Medicinal Chemistry Inflammatory Markers in Essential Hypertension: Potential Clinical Implications
Current Vascular Pharmacology The Correlated Factors of Serum CA19-9 Levels in Diabetic Patients
Current Diabetes Reviews Effect of the Surfactant and Liquid Lipid Type in the Physico-chemical Characteristics of Beeswax-based Nanostructured Lipid Carrier (NLC) of Metformin
Pharmaceutical Nanotechnology Nicotine Addiction and Coronary Artery Disease: Impact of Cessation Interventions
Current Pharmaceutical Design Antioxidant Food Supplements and Obesity-Related Inflammation
Current Medicinal Chemistry Vascular Endothelial Growth Factor (VEGF) in the Pathogenesis of Diabetic Nephropathy of Type 1 Diabetes Mellitus
Current Drug Targets Pathogenesis of Type 1 Diabetes: Regulation of Adhesion Molecules and Immune Cell Trafficking
Current Immunology Reviews (Discontinued) Sample Size Estimation for Negative Binomial Regression Models with Distinct Shape Parameters
Applied Clinical Research, Clinical Trials and Regulatory Affairs Potential Benefits and Limits of Psychopharmacological Therapies in Pervasive Developmental Disorders
Current Clinical Pharmacology The Use of Infliximab in Dermatology
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry A Review of Inadequate and Excessive Weight Gain in Pregnancy
Current Women`s Health Reviews Psychotropics and Fertility
Current Women`s Health Reviews The Diagnostic and Prognostic Value of Brain Natriuretic Peptide and Aminoterminal (nt)-pro Brain Natriuretic Peptide
Current Pharmaceutical Design The Role of Atypical Antipsychotic Agents in the Treatment of Schizophrenia and Schizoaffective Disorders in the Elderly
Current Drug Safety Hypertension in Pregnancy: Pathophysiology & Management Strategies
Current Pharmaceutical Design Cardiovascular Changes in Menopause
Current Cardiology Reviews Management Of Elderly Patients With Diffuse Large B-Cell Lymphomas
Anti-Cancer Agents in Medicinal Chemistry