Abstract
2-Isothiocyanatobenzonitrile (ITCB) and isocyanatobenzonitrile (ICB) represent versatile difunctional building blocks containing a nitrile and an isothiocyanate or an isocyanate function, respectively. The present review provides an account of the chemistry of ITCB and ICB. This includes a number of one-pot cyclizations which provide a convenient access to a variety of pharmacologically important heterocycles.
Keywords: 2-Isothiocyanatobenzonitrile (ITCB), isocyanatobenzonitrile (ICB), Organic Synthesis, Building Blocks, isocyanate function, one-pot cyclizations, heterocycles
Current Organic Chemistry
Title: 2-Isocyanatobenzonitrile and 2-Isothiocyanatobenzonitrile - Versatile Building Blocks in Organic Synthesis
Volume: 13 Issue: 10
Author(s): Franziska Bendrath and Peter Langer
Affiliation:
Keywords: 2-Isothiocyanatobenzonitrile (ITCB), isocyanatobenzonitrile (ICB), Organic Synthesis, Building Blocks, isocyanate function, one-pot cyclizations, heterocycles
Abstract: 2-Isothiocyanatobenzonitrile (ITCB) and isocyanatobenzonitrile (ICB) represent versatile difunctional building blocks containing a nitrile and an isothiocyanate or an isocyanate function, respectively. The present review provides an account of the chemistry of ITCB and ICB. This includes a number of one-pot cyclizations which provide a convenient access to a variety of pharmacologically important heterocycles.
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Cite this article as:
Bendrath Franziska and Langer Peter, 2-Isocyanatobenzonitrile and 2-Isothiocyanatobenzonitrile - Versatile Building Blocks in Organic Synthesis, Current Organic Chemistry 2009; 13 (10) . https://dx.doi.org/10.2174/138527209788680763
DOI https://dx.doi.org/10.2174/138527209788680763 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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