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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

2-Isocyanatobenzonitrile and 2-Isothiocyanatobenzonitrile - Versatile Building Blocks in Organic Synthesis

Author(s): Franziska Bendrath and Peter Langer

Volume 13, Issue 10, 2009

Page: [955 - 964] Pages: 10

DOI: 10.2174/138527209788680763

Price: $65

Abstract

2-Isothiocyanatobenzonitrile (ITCB) and isocyanatobenzonitrile (ICB) represent versatile difunctional building blocks containing a nitrile and an isothiocyanate or an isocyanate function, respectively. The present review provides an account of the chemistry of ITCB and ICB. This includes a number of one-pot cyclizations which provide a convenient access to a variety of pharmacologically important heterocycles.

Keywords: 2-Isothiocyanatobenzonitrile (ITCB), isocyanatobenzonitrile (ICB), Organic Synthesis, Building Blocks, isocyanate function, one-pot cyclizations, heterocycles


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