Abstract
Dopamine and serotonin are important neurotransmitters in the mammalian central nervous system (CNS) involved in numerous physiological and behavioural disorders such as schizophrenia, major depression, anxiety, Parkinsons and Huntingtons diseases, and attention deficit hyperactivity disorder. Several natural and synthetic benzylisoquinoline derivatives have displayed affinity for dopamine and serotonin receptors in nanomolar or micromolar ranges. This review covers the last three decades of dopaminergic and serotonergic activities, and especially focuses on structureactivity relationships of natural and synthetic benzylisoquinoline derivatives. We have included aporphines, 1- benzyltetrahydroisoquinolines, bis-benzylisoquinolines, protoberberines, cularines and other structural analogues. Further molecular modelling calculations have been considered as important tools to not only obtain structural information of both neurotransmitter receptors, but to also identify their pharmacophore features. The development of selective potential ligands like benzylisoquinoline derivatives may help in the therapy of diseases related to CNS dysfunction.
Keywords: Benzylisoquinoline derivatives, Dopamine receptors, Serotonin receptors, Structure-activity relationships, Molecular modelling
Current Medicinal Chemistry
Title: An Overview on Benzylisoquinoline Derivatives with Dopaminergic and Serotonergic Activities
Volume: 16 Issue: 19
Author(s): N. Cabedo, I. Berenguer, B. Figadere and D. Cortes
Affiliation:
Keywords: Benzylisoquinoline derivatives, Dopamine receptors, Serotonin receptors, Structure-activity relationships, Molecular modelling
Abstract: Dopamine and serotonin are important neurotransmitters in the mammalian central nervous system (CNS) involved in numerous physiological and behavioural disorders such as schizophrenia, major depression, anxiety, Parkinsons and Huntingtons diseases, and attention deficit hyperactivity disorder. Several natural and synthetic benzylisoquinoline derivatives have displayed affinity for dopamine and serotonin receptors in nanomolar or micromolar ranges. This review covers the last three decades of dopaminergic and serotonergic activities, and especially focuses on structureactivity relationships of natural and synthetic benzylisoquinoline derivatives. We have included aporphines, 1- benzyltetrahydroisoquinolines, bis-benzylisoquinolines, protoberberines, cularines and other structural analogues. Further molecular modelling calculations have been considered as important tools to not only obtain structural information of both neurotransmitter receptors, but to also identify their pharmacophore features. The development of selective potential ligands like benzylisoquinoline derivatives may help in the therapy of diseases related to CNS dysfunction.
Export Options
About this article
Cite this article as:
Cabedo N., Berenguer I., Figadere B. and Cortes D., An Overview on Benzylisoquinoline Derivatives with Dopaminergic and Serotonergic Activities, Current Medicinal Chemistry 2009; 16 (19) . https://dx.doi.org/10.2174/092986709788682100
DOI https://dx.doi.org/10.2174/092986709788682100 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Acknowledgements to Reviewers
CNS & Neurological Disorders - Drug Targets Role of Advanced Glycation End Products (AGEs) in Thrombogenic Abnormalities in Diabetes
Current Neurovascular Research ABC Subfamily D Proteins and Very Long Chain Fatty Acid Metabolism as Novel Targets in Adrenoleukodystrophy
Current Drug Targets A Pilot Study of Exenatide Actions in Alzheimer’s Disease
Current Alzheimer Research Pharmacological Treatment of Obesity: Current Standards and Future Perspectives
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Lamotrigine Induced Whole Body Tics: A Case Report and Literature Review
Current Drug Safety Meet Our Editorial Board Member
Mini-Reviews in Medicinal Chemistry Adalimumab
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Clinical Observation of Electroencephalographic Changes and Risk of Convulsion Occurrence in Children Receiving Neural Precursor Cell Transplantation
CNS & Neurological Disorders - Drug Targets The Injured Cochlea as a Target for Inflammatory Processes, Initiation of Cell Death Pathways and Application of Related Otoprotective Strategies
Recent Patents on CNS Drug Discovery (Discontinued) Iodine Deficiency and Iodine Prophylaxis in Pregnancy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery ACKNOWLEDGEMENTS TO THE REVIEWERS
CNS & Neurological Disorders - Drug Targets New Developments in Understanding and Treating Adolescent Marijuana Dependence
Adolescent Psychiatry Autophagy in Diabetic Retinopathy
Current Neuropharmacology Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 Patients
CNS & Neurological Disorders - Drug Targets Neuroimaging Studies of Substance Abuse in Schizophrenia
Current Psychiatry Reviews Epigenetic and Disease Targets by Polyphenols
Current Pharmaceutical Design Function and Regulation of Tumor Necrosis Factor Receptor Type 2
Current Medicinal Chemistry The Wnt/β-catenin Signalling Pathway Inhibitor Sclerostin is a Biomarker for Early Atherosclerosis in Obesity
Current Neurovascular Research Purinergic P2X Receptors: Structural and Functional Features Depicted by X-Ray and Molecular Modelling Studies
Current Medicinal Chemistry