Abstract
Since Virchow first proposed in 1863 that tumors could originate from sites of chronic inflammation, it has been well established that chronic inflammation both contributes to cancer progression and predisposes tissue to various types of cancer. Experimental, clinical, and epidemiological studies have all demonstrated the strong association between chronic inflammation and cancer, and many studies have correlated the prolonged presence of the inflammatory milieu with an increased risk for developing cancer. Proinflammatory cytokines, chemokines and adhesion molecules, which regulate the sequential recruitment of leukocytes, are frequently observed in tumor microenvironment. These early desmoplastic changes could stimulate fibroblasts and endothelial cell division and produce components for tissue remodeling and neovascularization, ultimately promoting neoplastic processes. In this review article we overview the current understanding of the role of chronic inflammation in neoangiogenesis, tumor initiation, promotion, and progression.
Keywords: Inflammation, microenvironment, neoangiogenesis, cancer
Current Pharmaceutical Design
Title: Inflammation, Microenvironment, and the Immune System in Cancer Progression
Volume: 15 Issue: 17
Author(s): Andrew Keibel, Vinod Singh and Mahesh C. Sharma
Affiliation:
Keywords: Inflammation, microenvironment, neoangiogenesis, cancer
Abstract: Since Virchow first proposed in 1863 that tumors could originate from sites of chronic inflammation, it has been well established that chronic inflammation both contributes to cancer progression and predisposes tissue to various types of cancer. Experimental, clinical, and epidemiological studies have all demonstrated the strong association between chronic inflammation and cancer, and many studies have correlated the prolonged presence of the inflammatory milieu with an increased risk for developing cancer. Proinflammatory cytokines, chemokines and adhesion molecules, which regulate the sequential recruitment of leukocytes, are frequently observed in tumor microenvironment. These early desmoplastic changes could stimulate fibroblasts and endothelial cell division and produce components for tissue remodeling and neovascularization, ultimately promoting neoplastic processes. In this review article we overview the current understanding of the role of chronic inflammation in neoangiogenesis, tumor initiation, promotion, and progression.
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Cite this article as:
Keibel Andrew, Singh Vinod and Sharma C. Mahesh, Inflammation, Microenvironment, and the Immune System in Cancer Progression, Current Pharmaceutical Design 2009; 15 (17) . https://dx.doi.org/10.2174/138161209788453167
DOI https://dx.doi.org/10.2174/138161209788453167 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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