Abstract
Microfluidic devices on chip-based systems are becoming increasingly popular, because of many advantages, like low mobile phase consumption and greatly reduced analysis times. The ultimate goal is to design all-including labon- a-chip tools that can be employed in the field and that integrate all elements necessary for an analysis, e.g. one or more separation channels, (multiple) detectors, mixing chambers and sample pretreatment areas. The chip format permits to make any channel pattern, rendering the applications of lab-on-a-chip unlimited. However, overcoming the limitations inherent with the detection systems remains a challenging problem. Whereas UV-detection is predominant in the larger systems, its sensitivity is inadequate due to the minute pathlengths employed in a chip. This review summarizes the shortcomings of UV detection, and discusses some possible solutions. Besides, it presents an overview of the alternative detection methods that have been employed in pharmaceutical and chiral chip analysis, including their positive and negative aspects as well. Finally, the applications reported on the chips are discussed.
Keywords: Detection, Microfluidic device, Lab-on-chip system, Pharmaceutical analysis, Chiral separation
Current Pharmaceutical Analysis
Title: Detection Systems for Microfluidic Devices with a Major Focus on Pharmaceutical and Chiral Analysis
Volume: 5 Issue: 2
Author(s): I. Tanret, D. Mangelings and Y. Vander Heyden
Affiliation:
Keywords: Detection, Microfluidic device, Lab-on-chip system, Pharmaceutical analysis, Chiral separation
Abstract: Microfluidic devices on chip-based systems are becoming increasingly popular, because of many advantages, like low mobile phase consumption and greatly reduced analysis times. The ultimate goal is to design all-including labon- a-chip tools that can be employed in the field and that integrate all elements necessary for an analysis, e.g. one or more separation channels, (multiple) detectors, mixing chambers and sample pretreatment areas. The chip format permits to make any channel pattern, rendering the applications of lab-on-a-chip unlimited. However, overcoming the limitations inherent with the detection systems remains a challenging problem. Whereas UV-detection is predominant in the larger systems, its sensitivity is inadequate due to the minute pathlengths employed in a chip. This review summarizes the shortcomings of UV detection, and discusses some possible solutions. Besides, it presents an overview of the alternative detection methods that have been employed in pharmaceutical and chiral chip analysis, including their positive and negative aspects as well. Finally, the applications reported on the chips are discussed.
Export Options
About this article
Cite this article as:
Tanret I., Mangelings D. and Heyden Vander Y., Detection Systems for Microfluidic Devices with a Major Focus on Pharmaceutical and Chiral Analysis, Current Pharmaceutical Analysis 2009; 5 (2) . https://dx.doi.org/10.2174/157341209788172951
DOI https://dx.doi.org/10.2174/157341209788172951 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial [Hot topic: Target Therapy of Bone Metastases and Tumours (Guest Editors: M. Caraglia and D. Santini)]
Current Cancer Drug Targets The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind
Current Neuropharmacology QSAR Study on a Series of Aryl Carboxylic Acid Amide Derivatives as Potential Inhibitors of Dihydroorotate Dehydrogenase (DHODH)
Medicinal Chemistry Role of Phytochemicals in the Prevention of Menopausal Bone Loss: Evidence from In Vitro and In Vivo, Human Interventional and Pharmacokinetic Studies
Current Medicinal Chemistry Matrix Metalloproteinases: New Routes to the Use of MT1-MMP As A Therapeutic Target in Angiogenesis-Related Disease
Current Pharmaceutical Design Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity
Current Medicinal Chemistry The Association of Chemotherapy and Radiotherapy: Biological Rationale
Current Drug Therapy Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice
Current Medicinal Chemistry Fenofibrate: A New Treatment for Diabetic Retinopathy. Molecular Mechanisms and Future Perspectives
Current Medicinal Chemistry Gene Therapy of Chronic Pain
Current Gene Therapy Lesions and Dysfunctions of the Nucleus Basalis as Alzheimers Disease Models: General and Critical Overview and Analysis of the Long-Term Changes in Several Excitotoxic Models
Current Alzheimer Research Astrocyte Influences on Ischemic Neuronal Death
Current Molecular Medicine The Role of Phospholipase A2 and Lipoxygenases Associated with Arachidonic Acid in Oxidative Stress-Induced Cell Injury
Current Enzyme Inhibition Progranulin, a New Adipokine at the Crossroads of Metabolic Syndrome, Diabetes, Dyslipidemia and Hypertension
Current Pharmaceutical Design Cross-Talk between Tumor Cells and the Microenvironment at the Metastatic Niche
Current Pharmaceutical Biotechnology Plant Pathogen Recognition as a Natural, Original and Simple Model for Chemogenomics: A Brief Overview of Cell-Based Assays to Screen for Peptides Acting as Plant Defense Activators
Combinatorial Chemistry & High Throughput Screening Anaemia, Polycythaemia and Chronic Heart Failure
Current Cardiology Reviews Reduction in Ischemic Cerebral Infarction is Mediated through Golgi Phosphoprotein 3 and Akt/mTOR Signaling Following Salvianolate Administration
Current Neurovascular Research How to Manage the Risk of Colorectal Cancer in Ulcerative Colitis
Current Drug Targets Novel Delivery Technologies: Triggering the Biopharmaceutical Potential of Boswellic Acids
The Natural Products Journal