Abstract
Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma and neuroblastoma and are frequently associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell cycle progression, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the proliferation-promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we will give an overview of Myc activation in embryonal tumors and discuss current strategies aimed at targeting Myc for cancer treatment.
Keywords: Cancer, child, brain tumor, neuroblastoma, targeted therapies, Myc
Current Cancer Drug Targets
Title: Targeting Myc in Pediatric Malignancies of the Central and Peripheral Nervous System
Volume: 9 Issue: 2
Author(s): Michael A. Grotzer, Deborah Castelletti, Giulio Fiaschetti, Tarek Shalaby and Alexandre Arcaro
Affiliation:
Keywords: Cancer, child, brain tumor, neuroblastoma, targeted therapies, Myc
Abstract: Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma and neuroblastoma and are frequently associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell cycle progression, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the proliferation-promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we will give an overview of Myc activation in embryonal tumors and discuss current strategies aimed at targeting Myc for cancer treatment.
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Cite this article as:
Grotzer A. Michael, Castelletti Deborah, Fiaschetti Giulio, Shalaby Tarek and Arcaro Alexandre, Targeting Myc in Pediatric Malignancies of the Central and Peripheral Nervous System, Current Cancer Drug Targets 2009; 9 (2) . https://dx.doi.org/10.2174/156800909787580962
DOI https://dx.doi.org/10.2174/156800909787580962 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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