Abstract
The morbidity and mortality of coronary heart disease and of heart failure remain unacceptably high despite major advances in their management. The main focus of treatment has been revascularisation for ischaemic heart disease and neuro-humoral modification for heart failure. There is an urgent need for new modalities of treatment to improve mortality and morbidity. Recently, there has been a great deal of interest in the role of disturbances in cardiac energetics and myocardial metabolism in the pathophysiology of both ischaemic heart disease and heart failure and of therapeutic potential of metabolic modulation. The myocardium is a metabolic omnivore, but mainly uses fatty acids and glucose for generation of Adenosine-5-triphosphate (ATP). This review focuses on the key changes that occur to the metabolism of the heart in ischaemia and in heart failure and its effects on cardiac energetics.
Keywords: Heart failure, ischaemia, myocardial metabolism, pathophysiology
Current Pharmaceutical Design
Title: The Heart Metabolism: Pathophysiological Aspects in Ischaemia and Heart Failure
Volume: 15 Issue: 8
Author(s): K. Abozguia, G. Nallur Shivu, I. Ahmed, T. T. Phan and M. P. Frenneaux
Affiliation:
Keywords: Heart failure, ischaemia, myocardial metabolism, pathophysiology
Abstract: The morbidity and mortality of coronary heart disease and of heart failure remain unacceptably high despite major advances in their management. The main focus of treatment has been revascularisation for ischaemic heart disease and neuro-humoral modification for heart failure. There is an urgent need for new modalities of treatment to improve mortality and morbidity. Recently, there has been a great deal of interest in the role of disturbances in cardiac energetics and myocardial metabolism in the pathophysiology of both ischaemic heart disease and heart failure and of therapeutic potential of metabolic modulation. The myocardium is a metabolic omnivore, but mainly uses fatty acids and glucose for generation of Adenosine-5-triphosphate (ATP). This review focuses on the key changes that occur to the metabolism of the heart in ischaemia and in heart failure and its effects on cardiac energetics.
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Cite this article as:
Abozguia K., Shivu Nallur G., Ahmed I., Phan T. T. and Frenneaux P. M., The Heart Metabolism: Pathophysiological Aspects in Ischaemia and Heart Failure, Current Pharmaceutical Design 2009; 15 (8) . https://dx.doi.org/10.2174/138161209787582101
DOI https://dx.doi.org/10.2174/138161209787582101 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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